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A Meta-Analysis of the Prevalence of Class 1 Integron and Correlation With Antibiotic Resistance in Pseudomonas Aeruginosa Recovered From Iranian Burn Patients Publisher Pubmed



Heidarzadeh S1 ; Kaliji YE2 ; Pourpaknia R3 ; Mohammadzadeh A4 ; Ghazalibina M5 ; Saburi E6 ; Vazini H7 ; Khaledi A8, 9
Authors
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Authors Affiliations
  1. 1. Department of Microbiology and Virology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
  2. 2. Department of Microbiology, North Tehran Branch, Islamic Azad University, Tehran, Iran
  3. 3. Department of Medical Genetics, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
  4. 4. Department of Microbiology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
  5. 5. Department of Microbiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Nursing Department Basic Sciences Faculty, Hamedan Branch, Islamic Azad University, Hamadan, Iran
  8. 8. Infectious Diseases Research Center, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  9. 9. Department of Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran

Source: Journal of Burn Care and Research Published:2019


Abstract

The role of integrons has been highlighted in antibiotic resistance among Pseudomonas aeruginosa isolates. Therefore, we here reviewed the prevalence of class 1 integrons and their correlations with antibiotic resistance of P. aeruginosa isolated from Iranian burn patients. This review was conducted according to the guidelines of Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA). Cross-sectional and cohort studies published from January 1, 2000 until December 31, 2018 were enrolled. Meta-analysis was performed by Comprehensive Meta-Analysis (CMA) software using the random effects model, Cochran’s Q, and I2 tests. Publication bias was estimated by Funnel plot and Egger’s linear regression test. Nine out of 819 studies met the eligibility criteria. The overall combined prevalence of class 1 integrons in P. aeruginosa isolates was 69% (95% confidence interval [CI]: 50.5–83%). The highest combined resistance was reported against Cloxacillin (87.7%), followed by Carbenicillin (79.1%) and Ceftriaxone (77.3%). The combined prevalence of multidrug-resistant (MDR) isolates was 79.3% (95% CI: 31.1–97%). Also, a significant correlation was noted between the presence of class 1 integrons and antibiotic resistance in 55.5% of the included studies (P < .05). The results showed high prevalence of class 1 integrons, antibiotic resistance, and MDR strains in P. aeruginosa isolated from Iranian burn patients. Also, most of the included studies showed a significant correlation between the presence of class 1 integrons and antibiotic resistance. © American Burn Association 2019. All rights reserved.
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