Differences in the Interaction Between Cetp Taq1b Polymorphism and Dietary Fat Intake on Lipid Profile of Normolipedemic and Dyslipidemic Patients With Type 2 Diabetes Mellitus Publisher Pubmed



Kalantar Z¹ ; Eshraghian MR² ; Sotoudeh G³ ; Djalali M¹ ; Mansouri A⁴ ; Alvandi E¹ ; Javadi F⁵ ; Mahmoudi M¹ ; Koohdani F^{1, 6} Show Affiliations
Source: Clinical Nutrition Published:2018

Abstract

Background & aim: Dyslipidemia is one of the major complications in patients with type 2 diabetes mellitus (T2DM). Dietary fat intake and genetic factors including CETP Taq1B polymorphism could also affect lipid profile concentrations, in particular HDL-c. We decided to study the frequency of this polymorphism and its interaction with dietary fat intake on HDL-c concentration among Iranian T2DM patients with and without dyslipidemia. Methods: In this comparative study, serum samples were collected from 55 patients with dyslipidemia and 129 patients without dyslipidemia. Validated semi-quantitative FFQ was used for food consumption data. CETP Taq1B polymorphism was studied by polymerase chain reaction-restriction length polymorphism (PCR-RFLP). We used χ 2 and two-way ANOVA tests for statistical analysis. Results: The frequency of B1B1 genotype was higher in patients with dyslipidemia (p = 0.01). There was no significant relationship between CETP Taq1B polymorphism and lipid profile concentrations. In patients without dyslipidemia, the interaction between the polymorphism and total fat intake on HDL-c concentration as well as TG/HDL ratio was significant (p = 0.02 and p = 0.009 respectively). This was more evident in B1B1 genotype. Moreover, HDL-c concentration was significantly higher in B2B2 genotype with low total fat intake. Conclusion: Higher total fat intake may affect the relationship between CETP Taq1B polymorphism and HDL-c concentration in patients with normolipidemic T2DM. © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism