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Simultaneous Detection of Opportunistic Viral Infections Among Renal Transplant Patients From Sina Hospital, Tehran Publisher



Rahbar M1 ; Amiri M1 ; Poormand G2 ; Poortahmasebi V3, 4, 5 ; Karkhaneh MM6 ; Jazayeri A1 ; Jazayeri SM5, 6
Authors
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Authors Affiliations
  1. 1. Department of Nephrology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Urology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Iran
  4. 4. Department of Bacteriology and Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Hepatitis B Molecular Laboratory, Department of Virology, Tehran University of Medical Sciences, Tehran, Iran

Source: Future Virology Published:2019


Abstract

Aim: A proportion of renal transplant (RT) recipients are at high risk for acquisition of opportunistic infections. Methods: A total of 101 plasma and urine specimens were collected from RT patients with raised plasma creatinine. These were tested for three common viral pathogens under suspicion of post-transplant nephropathy. Results: A total of 19 (18.8%), 15 (14.8%) and 10 (9.9%) tested positive for BK virus, cytomegalovirus and Epstein-Barr virus in their plasma and/or urine, respectively. Out of the 19 BK virus positive patients, 12 (63%) were in the tested plasma samples and 17 (89%) were in the urine samples. Four asymptomatic patients had high levels of Epstein-Barr virus shedding in their urine. No co-infected patients showed nephropathy. Conclusion: Relying on plasma creatinine rising levels alone may be an unreliable indicator for evaluating opportunistic viral infections in post-transplant RT subjects. © 2019 Future Medicine Ltd.