Cerebellar Degeneration in Primary Sjogren Syndrome Publisher Pubmed



Heidary M¹ ; Alesaeidi S^{2, 3} ; Afshari K⁴ Show Affiliations
Source: BMJ Case Reports Published:2018

Abstract

Neurological manifestations are reported as a consequence of primary Sjogren syndrome (PSS). Any part of the brain and peripheral nervous system can be involved in PSS. However, cerebellar degeneration and atrophy associated with PSS have been rarely reported. Our report describes a 22-year-old woman who presented with cerebellar ataxia, arthritis and arthralgia. Evaluation of her symptoms, autoantibodies and salivary gland pathology was in favour of the diagnosis of Sjogren syndrome. Also, her brain MRI revealed cerebellar degeneration. There are only four patients reported to be affected by cerebellar atrophy associated with PSS. Administration of high doses of methylprednisolone and cyclophosphamide leads to substantial improvement in the cerebellar symptoms of this case. In addition, after 2 months of follow-up, the patient's ataxia recovered significantly. It could be concluded that in addition to neurological degenerative disorders, in some cases cerebellar atrophy could also be associated with autoimmune conditions such as PSS. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved.