Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Efficacy of a Persian Medicine Herbal Compound (Alcea Digitata Alef and Malva Sylvestris L.) on Prevention of Radiation Induced Acute Mucositis in Patients With Head and Neck Cancer: A Pilot Study Publisher



Rezaeipour N1 ; Jafari F2 ; Rezaeizadeh H3 ; Nasseri M4 ; Kamalinejad M5 ; Ghobadi A6 ; Shamsipour M7 ; Zargaran A8 ; Ameri A9
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Traditional Medicine, School of Medicine, Shahed University, Tehran, Iran
  2. 2. Department of Health and Social Medicine, School of Medicine, Shahed University, Tehran, Iran
  3. 3. Department of Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran
  5. 5. Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Traditional Pharmacy, School of Traditional Medicine, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Research Methodology and Data Analysis, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Radiation Oncology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: International Journal of Cancer Management Published:2017


Abstract

Background: Mucositis is the most common complication of radiotherapy in patients with head and neck (H and N) cancers. Objectives: This study surveyed the efficacy of a herbal compound containing Alcea digitata Alef and Malva sylvestris L. in prevention of radiation-induced mucositis in patients with head and neck cancer. Methods: In the present study, a total of 23 patients were examined and assigned to 2 groups. The herbal drug and the placebo (provided from Avicel) were administered for 7 weeks, from the beginning of radiotherapy to 2 weeks after the completion of the treatment. During weekly visits, mouth pain score (MPS) was assessed, using visual analog scale (VAS) and severity of mucositis was checked by investigators. Results: Patients in control group showed more severe mucositis from second week, compared with drug group (p < 0.0001). The effect of herbal compound, time and the time-drug’s interaction on mucositis, and MPS were significant (p < 0.0001), hence, the severity of mucositis and the mean of MPS in control group was significantly more severe in comparison with drug group (p < 0.0001) in weekly cut. The effect of time was significant only in control group (p < 0.0001), and in drug group, there was no significant difference in severity of mucositis and MPS during the study (p = 0.2366). Conclusions: Therefore, not only the severity of mucositis and the average of MPS were significantly lower in drug group compared with control group, but also they were invariant during the study and showed no uptrend. © 2017, Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences.
Related Docs
1. Evaluation of Efficacy of an Herbal Compound on Dry Mouth in Patients With Head and Neck Cancers: A Randomized Clinical Trial, Journal of Evidence-Based Complementary and Alternative Medicine (2016)
2. Efficacy of a Traditional Persian Medicine Preparation for Radiation-Induced Xerostomia: A Randomized, Open-Label, Active-Controlled Trial, Journal of Integrative Medicine (2017)
3. Medicinal Plants Contain Mucilage Used in Traditional Persian Medicine (Tpm), Pharmaceutical Biology (2015)
4. The Effect of the Combination of Malva Sylvestris L. and Althaea Digitata Boiss. on Prevention of Acute Radiation Proctitis in Patients With Prostate Cancer, Journal of Herbal Medicine (2018)
5. Convenient, Traditional and Alternative Therapies for Cardiovascular Disorders, Current Pharmaceutical Design (2017)
Experts (# of related papers)
View all Related Experts
Hossein Rezaeizadeh (4)
Arman Zargaran (1)