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Brain Energy Metabolism Changes and Neuropsychological Impairment in Parkinson Disease Vs Alzheimer Disease Publisher Pubmed



Khodadadi S ; Rezaeimanesh N ; Ariyae Motahar A ; Yousefi F ; Avateffazeli M ; Montazeri Shatouri R ; Hosseini E ; Sahab Negah S ; Naser Moghadasi A
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Source: International Review of Neurobiology Published:2026


Abstract

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative disorders, posing a significant public health risk. Although they are separate diseases, they have similar neuropsychological characteristics. Despite making up only a small portion of total body mass, the brain requires a disproportionately large amount of energy to maintain neuronal activity, synapse function, and cellular homeostasis. Disruption of energy metabolism is thus a major contributor to neurodegeneration. Energy metabolism has a wide-ranging impact on brain function, including cognitive and psychological processes, and gets increasingly compromised in neurodegenerative disorders. This chapter aims to offer a thorough overview of the link between altered brain energy metabolism and neuropsychological impairment in AD and PD. Copyright © 2026. Published by Elsevier Inc.
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