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Efficient Synthesis of Novel Thiazol-2-Ylidene-Amides Using Carbonylthiourea Building Blocks Publisher



Saeedi M1 ; Goli F1 ; Mahdavi M1 ; Asadipour A2 ; Shafiee A1 ; Foroumadi A1, 2
Authors

Source: Journal of Heterocyclic Chemistry Published:2015


Abstract

In this work, an efficient and versatile synthesis of novel thiazol-2-ylidene-amides from various carbonylthiourea derivatives is described. A sequential alkylation-cyclization reaction between thioureas and propargyl bromide in the presence of DABCO in refluxing ethanol afforded 4-methylthiazol-2(3H)-ylidene-amide derivatives in good yields. © 2014 HeteroCorporation.
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