Brief Communication: Comparison of Changes in Metabolic Parameters Following Antiretrovial Therapy With Treatment Regimens Containing Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate

Brief Communication: Comparison of Changes in Metabolic Parameters Following Antiretrovial Therapy With Treatment Regimens Containing Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate Publisher Pubmed

Mirmoezzi H¹ ; Koochak HE² ; Dehghan Manshadi SA² ; Hasannezhad M^{2, 3} ; Seyedalinaghi S³ ; Semnani K¹ ; Abbasian L^{2, 3} ; Ghaderkhani S^{2, 3}

Show Affiliations

1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Infectious Diseases, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Tehran, Iran
3. Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Iranian Institute for reduction of High- Risk Behaviors, Tehran, Iran

Source: AIDS Research and Therapy Published:2025

Abstract

Concerns of increased metabolic dysfunction have been heightened for HIV patients on long-term antiretroviral therapy (ART). Among first-line ART agents, Tenofovir alafenamide (TAF) may entail a marked increase in weight compared to Tenofovir disoproxil fumarate (TDF). We retrospectively evaluated changes in weight and glucose regulation among 153 treament-naive patients. Weight-gain was more pronounced after one year of treatment with TAF versus TDF (3.5 kg versus − 1 kg, P-value < 0.001). However, weight-gain was attenuated with longer follow-up, and no increase in glucose dysregulation was noted for TAF treatment. Attribution of increased metabolic risk to treatment with TAF remains questionable. © The Author(s) 2025.

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Style	Citing Format
MLA	Mirmoezzi H, et al.. "Brief Communication: Comparison of Changes in Metabolic Parameters Following Antiretrovial Therapy With Treatment Regimens Containing Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate." AIDS Research and Therapy, vol. 22, no. 1, 2025, pp. -.
APA	Mirmoezzi H, Koochak HE, Dehghan Manshadi SA, Hasannezhad M, Seyedalinaghi S, Semnani K, Abbasian L, Ghaderkhani S (2025). Brief Communication: Comparison of Changes in Metabolic Parameters Following Antiretrovial Therapy With Treatment Regimens Containing Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate. AIDS Research and Therapy, 22(1), -.
Chicago	Mirmoezzi H, Koochak HE, Dehghan Manshadi SA, Hasannezhad M, Seyedalinaghi S, Semnani K, Abbasian L, Ghaderkhani S. "Brief Communication: Comparison of Changes in Metabolic Parameters Following Antiretrovial Therapy With Treatment Regimens Containing Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate." AIDS Research and Therapy 22, no. 1 (2025): -.
Harvard	Mirmoezzi H et al. (2025) 'Brief Communication: Comparison of Changes in Metabolic Parameters Following Antiretrovial Therapy With Treatment Regimens Containing Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate', AIDS Research and Therapy, 22(1), pp. -.
Vancouver	Mirmoezzi H, Koochak HE, Dehghan Manshadi SA, Hasannezhad M, Seyedalinaghi S, Semnani K, et al.. Brief Communication: Comparison of Changes in Metabolic Parameters Following Antiretrovial Therapy With Treatment Regimens Containing Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate. AIDS Research and Therapy. 2025;22(1):-.
BibTex	@article{ author = {Mirmoezzi H and Koochak HE and Dehghan Manshadi SA and Hasannezhad M and Seyedalinaghi S and Semnani K and Abbasian L and Ghaderkhani S}, title = {Brief Communication: Comparison of Changes in Metabolic Parameters Following Antiretrovial Therapy With Treatment Regimens Containing Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate}, journal = {AIDS Research and Therapy}, volume = {22}, number = {1}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Mirmoezzi H AU - Koochak HE AU - Dehghan Manshadi SA AU - Hasannezhad M AU - Seyedalinaghi S AU - Semnani K AU - Abbasian L AU - Ghaderkhani S TI - Brief Communication: Comparison of Changes in Metabolic Parameters Following Antiretrovial Therapy With Treatment Regimens Containing Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate JO - AIDS Research and Therapy VL - 22 IS - 1 SP - EP - PY - 2025 ER -

Style

Citing Format

MLA

Mirmoezzi H, et al.. "Brief Communication: Comparison of Changes in Metabolic Parameters Following Antiretrovial Therapy With Treatment Regimens Containing Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate." AIDS Research and Therapy, vol. 22, no. 1, 2025, pp. -.

APA

Mirmoezzi H, Koochak HE, Dehghan Manshadi SA, Hasannezhad M, Seyedalinaghi S, Semnani K, Abbasian L, Ghaderkhani S (2025). Brief Communication: Comparison of Changes in Metabolic Parameters Following Antiretrovial Therapy With Treatment Regimens Containing Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate. AIDS Research and Therapy, 22(1), -.

Chicago

Mirmoezzi H, Koochak HE, Dehghan Manshadi SA, Hasannezhad M, Seyedalinaghi S, Semnani K, Abbasian L, Ghaderkhani S. "Brief Communication: Comparison of Changes in Metabolic Parameters Following Antiretrovial Therapy With Treatment Regimens Containing Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate." AIDS Research and Therapy 22, no. 1 (2025): -.

Harvard

Mirmoezzi H et al. (2025) 'Brief Communication: Comparison of Changes in Metabolic Parameters Following Antiretrovial Therapy With Treatment Regimens Containing Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate', AIDS Research and Therapy, 22(1), pp. -.

Vancouver

Mirmoezzi H, Koochak HE, Dehghan Manshadi SA, Hasannezhad M, Seyedalinaghi S, Semnani K, et al.. Brief Communication: Comparison of Changes in Metabolic Parameters Following Antiretrovial Therapy With Treatment Regimens Containing Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate. AIDS Research and Therapy. 2025;22(1):-.

BibTex

@article{ author = {Mirmoezzi H and Koochak HE and Dehghan Manshadi SA and Hasannezhad M and Seyedalinaghi S and Semnani K and Abbasian L and Ghaderkhani S}, title = {Brief Communication: Comparison of Changes in Metabolic Parameters Following Antiretrovial Therapy With Treatment Regimens Containing Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate}, journal = {AIDS Research and Therapy}, volume = {22}, number = {1}, pages = {-}, year = {2025} }

RIS

TY - JOUR
AU - Mirmoezzi H
AU - Koochak HE
AU - Dehghan Manshadi SA
AU - Hasannezhad M
AU - Seyedalinaghi S
AU - Semnani K
AU - Abbasian L
AU - Ghaderkhani S
TI - Brief Communication: Comparison of Changes in Metabolic Parameters Following Antiretrovial Therapy With Treatment Regimens Containing Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate
JO - AIDS Research and Therapy
VL - 22
IS - 1
SP -
EP -
PY - 2025
ER -

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