Synthesis of Novel Nano-Radiotracer for In-Vivo Bone Imaging: 99Mtc- Citric Acid Based Peg Dendrimer and Its Conjugation With Alendronate

Synthesis of Novel Nano-Radiotracer for In-Vivo Bone Imaging: 99Mtc- Citric Acid Based Peg Dendrimer and Its Conjugation With Alendronate Publisher

Davoodikia B¹ ; Pirali Hamedani M² ; Saffari M³ ; Esmaeil Sadat Ebrahimi S² ; Seyyed Hamzeh M² ; Hashemi S² ; Shafiee Ardestani M² ; Masoumeh Ghoreishi S⁴

Show Affiliations

1. School of pharmacy international campus Tehran university of medical sciences, Tehran, Iran
2. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. Branch of Pharmaceutical Sciences, Islamic Azad University, Tehran, Iran.Department of Pharmaceutics & Medical Nanotechnology
4. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

Source: Arabian Journal of Chemistry Published:2022

Abstract

Bone scan is the test that guide physician to diagnose diseases in the bone at the early stage, to prevent metastases to other organs. In this study, citric acid dendrimer conjugation with alendronate was synthesized. Obtained product was confirmed by FT-IR and TEM. Cytotoxicity assay at different concentrations showed no toxicity on normal cell line compared to control group. Radiolabeling process was optimized by Box-Behnken software which is a computational method to determine optimum of important radiolabeling parameters. Optimized parameter for reducing agent, dendrimer-G2-alendronate, and time for shaking was 1 mg, 12.3 mg, and 25 min respectively. For determination of in-vivo accumulation of 99mTc-dendrimer-G2-alendronate, SPECT imaging was done. Images showed high accumulation of radio-tracer in the skeletal compared to 99mTc-MDP which is the frequent bone scan agent. All in all, obtained results confirmed our hypothesis that the dendrimer-G2-alendronate can be noteworthy nano-radiopharmaceuticals to bone cancer imaging at early stage. © 2022 The Author(s)

Style	Citing Format
MLA	Davoodikia B, et al.. "Synthesis of Novel Nano-Radiotracer for In-Vivo Bone Imaging: 99Mtc- Citric Acid Based Peg Dendrimer and Its Conjugation With Alendronate." Arabian Journal of Chemistry, vol. 15, no. 9, 2022, pp. -.
APA	Davoodikia B, Pirali Hamedani M, Saffari M, Esmaeil Sadat Ebrahimi S, Seyyed Hamzeh M, Hashemi S, Shafiee Ardestani M, Masoumeh Ghoreishi S (2022). Synthesis of Novel Nano-Radiotracer for In-Vivo Bone Imaging: 99Mtc- Citric Acid Based Peg Dendrimer and Its Conjugation With Alendronate. Arabian Journal of Chemistry, 15(9), -.
Chicago	Davoodikia B, Pirali Hamedani M, Saffari M, Esmaeil Sadat Ebrahimi S, Seyyed Hamzeh M, Hashemi S, Shafiee Ardestani M, Masoumeh Ghoreishi S. "Synthesis of Novel Nano-Radiotracer for In-Vivo Bone Imaging: 99Mtc- Citric Acid Based Peg Dendrimer and Its Conjugation With Alendronate." Arabian Journal of Chemistry 15, no. 9 (2022): -.
Harvard	Davoodikia B et al. (2022) 'Synthesis of Novel Nano-Radiotracer for In-Vivo Bone Imaging: 99Mtc- Citric Acid Based Peg Dendrimer and Its Conjugation With Alendronate', Arabian Journal of Chemistry, 15(9), pp. -.
Vancouver	Davoodikia B, Pirali Hamedani M, Saffari M, Esmaeil Sadat Ebrahimi S, Seyyed Hamzeh M, Hashemi S, et al.. Synthesis of Novel Nano-Radiotracer for In-Vivo Bone Imaging: 99Mtc- Citric Acid Based Peg Dendrimer and Its Conjugation With Alendronate. Arabian Journal of Chemistry. 2022;15(9):-.
BibTex	@article{ author = {Davoodikia B and Pirali Hamedani M and Saffari M and Esmaeil Sadat Ebrahimi S and Seyyed Hamzeh M and Hashemi S and Shafiee Ardestani M and Masoumeh Ghoreishi S}, title = {Synthesis of Novel Nano-Radiotracer for In-Vivo Bone Imaging: 99Mtc- Citric Acid Based Peg Dendrimer and Its Conjugation With Alendronate}, journal = {Arabian Journal of Chemistry}, volume = {15}, number = {9}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Davoodikia B AU - Pirali Hamedani M AU - Saffari M AU - Esmaeil Sadat Ebrahimi S AU - Seyyed Hamzeh M AU - Hashemi S AU - Shafiee Ardestani M AU - Masoumeh Ghoreishi S TI - Synthesis of Novel Nano-Radiotracer for In-Vivo Bone Imaging: 99Mtc- Citric Acid Based Peg Dendrimer and Its Conjugation With Alendronate JO - Arabian Journal of Chemistry VL - 15 IS - 9 SP - EP - PY - 2022 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract