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Design and Synthesis of New Benzofuran-1,2,3-Triazole Hybrid Preservatives and the Evaluation of Their Antifungal Potential Against White and Brown-Rot Fungi Publisher



Abedinifar F1 ; Farnia SMF1 ; Hosseinihashemi SK2 ; Jalaligoldeh A3 ; Arabahmadi S4 ; Mahdavi M5
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Authors Affiliations
  1. 1. Department of Chemistry, College of Science, University of Tehran, Tehran, Iran
  2. 2. Department of Wood Science and Paper Technology, Karaj Branch, Islamic Azad University, Karaj, Iran
  3. 3. Department of Horticulture, Karaj Branch, Islamic Azad University, Karaj, Iran
  4. 4. Department of Chemistry, University of Mazandaran, P. O. Box: 47416-95447, Babolsar, Iran
  5. 5. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Science Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: BioResources Published:2020


Abstract

A series of novel benzofuran-1,2,3-triazole hybrids were synthesized and investigated as fungicidal preservatives. The compounds were evaluated for their antifungal potential against white-rot (Trametes versicolor), dry brown-rot (Poria placenta), and wet brown-rot (Coniophora puteana and Gloeophyllum trabeum) fungi, at different concentrations (500 ppm and 1000 ppm). The tests of the final products (8a, 8b, 8c, 8d, 8e, 8f, and 8g) demonstrated that compound N-((1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)benzofuran-2-carboxamide (8f) at a concentration of 500 ppm was the most active against wet brown-rot C. puteana (23.86% inhibition) and G. trabeum (47.16% inhibition) fungi. However, testing demonstrated that compounds 8a, 8b, 8c, 8d, and 8g at a concentration of 500 ppm did not exhibit acceptable antifungal effects against white-rot T. versicolor and dry brown-rot P. placenta fungi. © 2021, BioResources. All rights reserved.
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