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How Do Experts Treat Patients With Bullous Pemphigoid Around the World? an International Survey Publisher



Guignant M1, 2 ; Tedbirt B1, 2 ; Murrell DF3 ; Amagai M4, 5 ; Aoki V6 ; Bauer J7 ; Ciancinni G8 ; Culton D9 ; Daneshpazhooh M10 ; De D11 ; Fairley J12, 13 ; Hall R14 ; Kim SC15 ; Korman NJ16 Show All Authors
Authors
  1. Guignant M1, 2
  2. Tedbirt B1, 2
  3. Murrell DF3
  4. Amagai M4, 5
  5. Aoki V6
  6. Bauer J7
  7. Ciancinni G8
  8. Culton D9
  9. Daneshpazhooh M10
  10. De D11
  11. Fairley J12, 13
  12. Hall R14
  13. Kim SC15
  14. Korman NJ16
  15. Kowalewski C17
  16. Mimouni D18, 19
  17. Patsatsi A20
  18. Hebert V1, 2
  19. Saleh MAM21
  20. Schmidt E22, 23
  21. Sprecher E24
  22. Uzun S25
  23. Venning V26
  24. Werth VP27
  25. Zillikens D22
  26. Joly P1, 2
Show Affiliations
Authors Affiliations
  1. 1. Department of Dermatology, Rouen University Hospital, Rouen, France
  2. 2. INSERM Unit 2345, French Reference Center for Autoimmune Bullous Diseases, Normandie University, Rouen, France
  3. 3. Department of Dermatology, St George Hospital, University of New South Wales Sydney, Kensington, Australia
  4. 4. Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
  5. 5. Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan
  6. 6. Department of Dermatology and Allergology, University of Sao Paulo, Sao Paulo, Brazil
  7. 7. Department of Dermatology, University Hospital of the Paracelsus Medical University, Salzburg, Austria
  8. 8. Department of Dermatology, Ospedale Classificato Cristo RE, Rome, Italy
  9. 9. Department of Dermatology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
  10. 10. Bullous Diseases Research Center, Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
  12. 12. Department of Dermatology, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
  13. 13. Department of Veterans Affairs Medical Center, U.S. Department of Veterans Affairs, Iowa City, IA, United States
  14. 14. Duke Dermatology, Duke University School of Medicine, Durham, NC, United States
  15. 15. Department of Dermatology, Gangnam Severance Hospital, Seoul, South Korea
  16. 16. Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States
  17. 17. Department of Dermatology and Immunodermatology, Medical University of Warsaw, Warsaw, Poland
  18. 18. Department of Dermatology, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
  19. 19. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  20. 20. Department of Dermatology, “Papageorgiou� General Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
  21. 21. Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt
  22. 22. Department of Dermatology, University of Lubeck, Lubeck, Germany
  23. 23. The Lubeck Institute of Experimental Dermatology (LIED), University of Lubeck, Lubeck, Germany
  24. 24. Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
  25. 25. Department of Dermatology and Venereology, Faculty of Medicine, Akdeniz University, Antalya, Turkey
  26. 26. Department of Dermatology, Churchill Hospital, Oxford, United Kingdom
  27. 27. Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Source: JID Innovations Published:2022


Abstract

Many treatments are currently proposed for treating patients with bullous pemphigoid (BP). We assessed treatment modalities of BP depending on the different countries, BP extent, and patients’ comorbidities. We surveyed worldwide experts about how they treat patients with BP. A total of 61 experts from 27 countries completed the survey. Severe and moderate BP were treated with oral prednisone (61.4 and 53.7%, respectively) or superpotent topical corticosteroids (CSs) (38.6 and 46.3%, respectively). Conventional immunosuppressants were more frequently combined with oral prednisone (74.5%) than with superpotent topical CS (37.5%) in severe BP. Topical CSs were mainly used in Europe in mild (81.1%), moderate (55.3%), and severe (54.3%) BP. In the United States of America and Asia, systemic CSs were mainly proposed for treating severe (77.8 and 100%, respectively), moderate (70 and 77.8%, respectively), and also mild (47.1 and 33.3%, respectively) BP. Most experts reduced the initial dose of oral CS in patients with diabetes mellitus (48.1%) or cardiac insufficiency (40.2%) but rarely changed BP treatment in patients with neurological disorders or neoplasia. This survey showed major differences in the way patients with BP are treated between AmeriPac countries (United State of America, Latin America, and Australia) and Asia on the one hand and Europe and the Middle East on the other hand. © 2022 The Authors