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Age-Dependent Effect of Chlorpyrifos on the Hematological Parameters in Male Rats Publisher



Roshanravan B1 ; Mehrpour O1, 2 ; Ashrafizadeh M3 ; Yazdanfar N4 ; Sadighara P5 ; Farkhondeh T1, 6 ; Samarghandian S7
Authors
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Authors Affiliations
  1. 1. Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences (BUMS), Birjand, Iran
  2. 2. Arizona Poison and Drug Information Center, the University of Arizona, college of pharmacy, Tucson, AZ, United States
  3. 3. Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
  4. 4. Iranian Institute of R&D in Chemical Industries (IRDCI) (ACECR), Tehran, Iran
  5. 5. Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran
  7. 7. Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran

Source: Toxin Reviews Published:2021


Abstract

The association between organophosphate pesticides (OPs) and hematological disorders has not fully understood. The current research aimed to evaluate the impact of sub-chronic exposure to chlorpyrifos (CPF), a potent OP, on the hematological parameters of male rats of different ages. For this reason, 48 male Wistar rats, including young (2-month old), middle-aged (10-month old), and aged (20-month old), were randomly divided into three control and three treatment groups as follows (n = 8, per each group): young control group (C2), young CPF-treated group (CPF2), middle-aged control group (C10), middle-aged CPF-treated group (CPF10), aged control group (C20) and aged CPF-treated group (CPF20). CPF (5 mg/kg, orally) was administrated for 45 days. The control animals were gavaged olive oil as a vehicle. The blood samples were gathered from the heart to assess values of the mean platelet volume (MPV), mean corpuscular hemoglobin (MCHC), mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV), platelets (PLT), hematocrit (Hct), hemoglobin (Hb), and the number of red blood cells (RBCs). The findings showed that CPF dramatically reduced the number of RBCs, Hct, Hb, MCH, and PLT values in the young rats versus the age-matched control rats. However, no marked differences were found between hematological parameters in aging rats versus age-matched controls. The present findings indicated that sub-chronic exposure to CPF caused anemia in young animals. It is proposed that young animals are more sensitive to the hepatotoxic impact of CPF than aging rats. However, more studies are needed to confirm the current findings. © 2020 Informa UK Limited, trading as Taylor & Francis Group.