Pachychoroid Neovasculopathy Versus Macular Neovascularization in Age-Related Macular Degeneration With and Without Shallow Irregular Pigment Epithelial Detachment Publisher Pubmed



Riaziesfahani H¹ ; Asadi Khameneh E^{1, 4} ; Ghassemi F¹ ; Mehrabi Bahar M¹ ; Torkashvand A² ; Mahmoudi A³ ; Husein Ahmed A¹ ; Faghihi S¹ ; Rahimi M¹ ; Akbarzadeh A¹ ; Faghihi H¹ ; Khalili Pour E¹ Show Affiliations
Source: Scientific Reports Published:2023

Abstract

To compare the choroidal neovascular features of individuals with pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) with and without shallow irregular pigment epithelial detachment (SIPED). Using optical coherence tomography angiography, the choroidal neovascular complexes of 27 patients with PNV, 34 patients with nAMD and SIPED, and 15 patients with nAMD without SIPED were analyzed with FIJI and AngioTool software. PNV compared to nAMD with SIPED had a greater vessel percentage area (P = 0.034), junction density (P = 0.045), average vessel length (P < 0.001), and fractal dimension (P < 0.001). PNV, compared to nAMD without SIPED, had a greater total vessel length (P = 0.002), total number of junctions (P < 0.001), junction density (P = 0.034), and fractal dimension (P = 0.005). nAMD with SIPED, compared to nAMD without SIPED, had greater vessel area, total number of junctions, total vessel length, and average vessel length (all P values < 0.001). Patients with nAMD plus SIPED and individuals with nAMD without SIPED have similar fractal dimension values (P = 0.703). Biomarkers of choroidal neovascular complexity, such as fractal dimension, can be used to differentiate PNV from nAMD with or without SIPED. © 2023, The Author(s).