Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Covid-19 Vaccination During Pregnancy: A Systematic Review and Meta-Analysis Publisher Pubmed



Shafiee A1, 2 ; Kohandel Gargari O2 ; Teymouri Athar MM3 ; Fathi H2 ; Ghaemi M4 ; Mozhgani SH5, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  2. 2. Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran
  3. 3. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Non-Communicable Disease Research Center, Alborz University of Medical Sciences, Karaj, Iran

Source: BMC Pregnancy and Childbirth Published:2023


Abstract

Background: SARS-CoV-2 exposure during pregnancy is related to adverse effects for both the mother and the infant. SARS-CoV-2 vaccination has lowered the risk of symptomatic disease substantially. Recently published studies have evaluated the outcomes of women who received the COVID-19 vaccine during pregnancy; systematic evidence regarding vaccination safety is crucial to ensure that COVID-19 vaccination is not associated with adverse pregnancy and neonatal outcomes. Methods: Pubmed/MEDLINE, EMBASE, Scopus, Web of Science, and Clinicaltrials.gov were searched from each database's inception through April 7, 2022. All interventional and observational studies comparing neonatal or pregnancy outcomes between pregnant women who received COVID-19 vaccines during their pregnancy and unvaccinated pregnant women were included. The random-effects model was used in the meta-analyses. Results: A total of 11 studies comprising 756,098 pregnant mothers were included. The rate of neonates with 5-min Apgar score ≤ 7 (log RR -0.08 (95% CI: -0.15 to -0.00), (P = 0.03)) and pregnant mothers with preterm birth (log RR -0.11 (95% CI: -0.21 to -0.01), (P = 0.02)) was significantly lower among vaccinated group. No significant difference was observed in adverse neonatal outcomes (log RR -0.07 (95% CI: -0.17 to 0.03)), small for gestational age (log RR -0.06 (95% CI: -0.14 to 0.02)), caesarean delivery (log RR 0.05 (95% CI: -0.05 to 0.15)), postpartum hemorrhage (log RR -0.05 (95% CI: -0.13 to 0.02)), stillbirth (log RR -0.05 (95% CI: -0.54 to 0.45)). Conclusions and relevance: In this systematic review and meta-analysis, no evident differences were observed when comparing vaccinated pregnant mothers with those who had not received COVID-19 vaccines. Based on low certainty of evidence, vaccination during pregnancy was accompanied by a favorable Apgar score in neonates and fewer preterm births. © 2023, The Author(s).
Related Docs
View other Related Docs
1. Perinatal Outcomes and Sinopharm Bbibp-Corv Vaccination During Pregnancy, BMC Pregnancy and Childbirth (2024)
2. Complications of Covid-19 Vaccines During Pregnancy; a Systematic Review, Archives of Academic Emergency Medicine (2022)
3. Side Effects and Short-Term Safety of Covid-19 Vaccines for Pregnant Women: A Case Study of Southeast Iran, Archives of Clinical Infectious Diseases (2023)
4. Effect of Spikogen Subunit Vaccine Administration During Pregnancy on Fetal Development of Rats, Clinical and Experimental Vaccine Research (2024)
5. Cytokines and Chemokines Profile in Encephalitis Patients: A Meta-Analysis, PLoS ONE (2022)
6. Comparing Y-Balance Test Between Chronic Low Back Pain and Healthy People; a Systematic Review and Meta-Analysis, Sport Sciences for Health (2023)
7. The Cochrane Risk of Bias Assessment Tool 2 (Rob 2) Versus the Original Rob: A Perspective on the Pros and Cons, Health Science Reports (2024)
8. Vertical Transmission and Maternal Passive Immunity Post-Sars-Cov-2, Future Virology (2023)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (4)
Mohammadreza Salehi (1)
Other Related Docs
9. Cord Blood Antibodies Following Bbibp-Corv (Sinopharm) Vaccination During Pregnancy, Immunity# Inflammation and Disease (2023)
10. Covid-19 Knowledge, Attitudes, and Practices Among Iranian Pregnant and Postpartum Women: A National Study, Journal of Obstetrics and Gynaecology Research (2023)