Lead Exposure and Asthma: An Overview of Observational and Experimental Studies Publisher



Farkhondeh T¹ ; Samarghandian S^{2, 3} ; Sadighara P⁴
Source: Toxin Reviews Published:2015

Abstract

Uncontrolled industrialization has released heavy metal pollution in the world. Heavy metal pollutants disrupt physiological homeostasis and organ functions. Recent studies have suggested an association between lead (Pb) exposure and the incidence and severity of asthma. The purpose of this review is to provide an evidence-based summary of the effects of lead exposure on asthma. An overview of scientific literatures linking this pollutant with asthma will be provided, followed by consideration of the mechanisms underlying Pb-induced asthma. Present findings indicate that Pb may be a factor in the development of asthma through altering oxidative stress, immune and inflammatory responses. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.