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Lead Exposure and Asthma: An Overview of Observational and Experimental Studies Publisher



Farkhondeh T1 ; Samarghandian S2, 3 ; Sadighara P4
Authors
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Authors Affiliations
  1. 1. Department of Agriculture, Payam Noor University, Tehran, Iran
  2. 2. Department of Basic Medical Sciences, Neyshabur University of Medical of Sciences, Neyshabur, Iran
  3. 3. Health Strategic Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran
  4. 4. Department of Environmental Health, Faculty of Public Health, University of Medical Sciences, Tehran, Iran

Source: Toxin Reviews Published:2015


Abstract

Uncontrolled industrialization has released heavy metal pollution in the world. Heavy metal pollutants disrupt physiological homeostasis and organ functions. Recent studies have suggested an association between lead (Pb) exposure and the incidence and severity of asthma. The purpose of this review is to provide an evidence-based summary of the effects of lead exposure on asthma. An overview of scientific literatures linking this pollutant with asthma will be provided, followed by consideration of the mechanisms underlying Pb-induced asthma. Present findings indicate that Pb may be a factor in the development of asthma through altering oxidative stress, immune and inflammatory responses. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.
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