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Early Post-Operative Acute Kidney Injury After Cardiac Transplantation: Incidence and Predictive Factors Publisher Pubmed



Jahangirifard A1 ; Ahmadi ZH2 ; Khalili N3 ; Naghashzadeh F4 ; Afshar A5 ; Amiri A6 ; Dalili N6
Authors
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Authors Affiliations
  1. 1. Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Cardiothoracic Surgery, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Cardiology, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Tracheal Diseases Research Center, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Chronic Kidney Disease Research Center (CKDRC), Department of Nephrology, Labbafinezhad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Clinical Transplantation Published:2021


Abstract

Background: Heart transplantation, as a therapeutic option for patients with advanced heart failure, possesses a high rate of morbidity and mortality. One of the complications associated with this procedure is the development of postoperative acute kidney injury (AKI). Material and methods: We aimed to evaluate the incidence of early postoperative AKI and the need for continuous renal replacement therapy (RRT) after heart transplantation. Data of 126 patients who underwent heart transplantation from January 2015 to November 2019 were collected. Statistical analysis was performed to identify the predictors of postoperative AKI. Results: Out of 126 patients, 74 (58.7 %) developed AKI and 13 (10%) required RRT after transplant. Independent predictors of AKI are shown to be factors associated with surgical procedures such as graft ischemic time as were previous cardiac operation, administered Voluven (starch) dose > 400 ml, and transfusion of more than four blood units. Conclusion: Our findings suggest that modifiable factors exist that can affect the risk of developing AKI following heart transplantation. © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.