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The Shift of Hbf to Hba Under Influence of Ska2 Gene; a Possible Link Between Cortisol and Hematopoietic Maturation in Term and Preterm Newborns Publisher Pubmed



Ijabi J1 ; Afrisham R2 ; Moradisardareh H2 ; Roozehdar P3 ; Seifi F4 ; Sahebkar A5, 6, 7 ; Ijabi R4
Authors
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Authors Affiliations
  1. 1. Department of Hematology, School of Allied Health, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Veterinary, Azad University, Garmsar Branch, Garmsar, Iran
  4. 4. Counseling and Reproductive Health Research Centre, Golestan University of Medical Sciences, Gorgan, Iran
  5. 5. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Endocrine# Metabolic and Immune Disorders - Drug Targets Published:2021


Abstract

Background: We hypothesized that the SKA2 gene can convert hemoglobin F to A leading to the maturity of the hematopoietic system by glucocorticoid hormone; so, the present study aimed to investigate the health outcome of newborns by using the effect of SKA2 gene on hematopoietic matu-ration. Methods: At first, 142 samples were divided into term and preterm. After sampling from the umbilical cord blood, the expression of SKA2 genes and HbA and F were evaluated by quantitative RT-PCR. The blood gases were measured by Campact 3 device. Finally, the cortisol level was measured by ELISA method and HbA and F levels were investigated by capillary electrophoresis. Results: The blood gases and Apgar scores were more favorable in term newborns (P <0.001). Levels of protein/expression of HbF in newborns with Apgar score greater than 7 was lower than that of the newborns with Apgar score below 7 (P <0.001). Cortisol and HbA levels were considerably higher in term newborns compared to the preterm ones (P <0.001). In the preterm and term groups, SKA2 gene expression had a positive and significant relationship with cortisol and HbA levels as well as a nega-tive relationship with the HbF level. In the preterm group, a positive and significant relationship was observed between the expression of SKA2 and HbF genes. Conclusion: The results revealed that the SKA2 gene affected hematopoietic maturation in preterm and term newborns and the health outcome of newborns improved by increasing HbA level. © 2021 Bentham Science Publishers.
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