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Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Poststroke Depression: A Systematic Review and Meta-Analysis Publisher Pubmed



Sarejloo S1 ; Abadifard E2 ; Othman ZJ3 ; Zafarani F4 ; Khanzadeh M4 ; Sadigheteghad S5 ; Farajdokht F5 ; Mohammadpoorasl A6 ; Khanzadeh S4
Authors
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Authors Affiliations
  1. 1. Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Physical Education and Sport Sciences, Cihan University, Erbil, Iraq
  4. 4. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Disease Markers Published:2022


Abstract

Objectives. Evidence shows that stroke-induced inflammatory responses play an essential role in the development of poststroke depression (PSD). The goal of this systematic review and meta-analysis was to critically evaluate the literature regarding the use of the neutrophil to lymphocyte ratio (NLR) as a reliable means to detect early PSD development, to help clinicians institute early interventions and improve outcomes. Methods. Electronic databases, including Web of Science, PubMed, Google Scholar, and Scopus, were searched, and eight studies were included. We assessed the certainty of the associations with GRADE methods. Results. We found that patients with PSD had higher NLR than the stroke patients with no depression (SMD=0.51; CI 95%=0.29-0.73, p<0.001). Also, we found a significantly higher PLR in the patients with PSD when compared to the stroke patients with no depression (SMD=0.66; CI 95%=0.19-1.13, p<0.001). Conclusion. These findings indicated that NLR and PLR could be considered inexpensive biomarkers for the prediction of PSD. © 2022 Shirin Sarejloo et al.
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