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Spray Freeze-Drying for Inhalation Application: Process and Formulation Variables Publisher Pubmed



Rostamnezhad M1 ; Jafari H2 ; Moradikhah F3 ; Bahrainian S4 ; Faghihi H5 ; Khalvati R6 ; Bafkary R7 ; Vatanara A1
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Food and Drug Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
  4. 4. Department of Pharmaceutics, School of Pharmacy, Aerosol Research Laboratory, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Food and Drug Administration, Mazandaran University of Medical Sciences, Sari, Iran
  7. 7. Tehran University of Medical Sciences, Tehran, Iran

Source: Pharmaceutical Development and Technology Published:2022


Abstract

High porous particles with specific aerodynamic properties were processed by the spray freeze-drying (SFD) method. Comprehensive knowledge about all aspects of the SFD method is required for particle engineering of various pharmaceutical products with good flow properties. In this review, different types of the SFD method, the most frequently employed excipients, properties of particles prepared by this method, and most recent approaches concerning SFD are summarized. Generally, this technique can prepare spherical-shaped particles with a highly porous interior structure, responsible for the very low density of powders. Increasing the solubility of spray freeze-dried formulations achieves the desired efficacy. Also, due to the high efficiency of SFD, by determining the different features of this method and optimizing the process by model-based studies, desirable results for various inhaled products can be achieved and significant progress can be made in the field of pulmonary drug delivery. © 2022 Informa UK Limited, trading as Taylor & Francis Group.
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