Leveraging Machine Learning Algorithms to Forecast Delayed Cerebral Ischemia Following Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis of 5,115 Participants Publisher Pubmed



Mohammadzadeh I^{1, 2} ; Niroomand B¹ ; Eini P³ ; Khaledian H⁴ ; Choubineh T⁵ ; Luzzi S^{6, 7} Show Affiliations
Source: Neurosurgical Review Published:2025

Abstract

It is feasible to predict delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) using Artificial intelligence (AI) algorithms, which may offer significant improvements in early diagnosis and patient management. This systematic review and meta-analysis evaluate the efficacy of machine learning (ML) in predicting DCI, aiming to integrate complex clinical data to enhance diagnostic accuracy. We searched PubMed, Scopus, Web of science, and Embase databases without restrictions until June 2024, applying PRISMA guidelines. Out of 1498 studies screened, 10 met our eligibility criteria involving ML approaches in patients with confirmed aSAH. The studies employed various ML algorithms and reported differential ML metrics outcomes. Meta-analysis was performed on eight studies, which resulted in a pooled sensitivity of 0.79 [95% CI: 0.63–0.89], specificity of 0.78[95% CI: 0.68–0.85], positive DLR of 3.54 [95% CI: 2.22–5.64] and the negative DLR of 0.28 [95% CI: 0.15–0.52], diagnostic odds ratio of 12.82 [95% CI: 4.66–35.28], the diagnostic score of 2.55 [95% CI: 1.54–3.56], and the area under the curve (AUC) of 0.85. These findings show significant diagnostic accuracy and demonstrate the potential of ML algorithms to significantly improve the predictability of DCI, implying that ML could impart a significant role on improving clinical decision making. However, variability in methodological approaches across studies shows a need for standardization to realize the full benefits of ML in clinical settings. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.