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Melatonin: A Smart Molecule in the Dna Repair System Publisher Pubmed



Mir SM1 ; Aliarab A2 ; Goodarzi G3, 4 ; Shirzad M5, 6 ; Jafari SM1 ; Qujeq D5, 6 ; Samavarchi Tehrani S3, 4 ; Asadi J1
Authors
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Authors Affiliations
  1. 1. Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  2. 2. Department of Clinical Biochemistry, School of Medicine, Tarbiat Modares University, Tehran, Iran
  3. 3. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
  6. 6. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

Source: Cell Biochemistry and Function Published:2022


Abstract

DNA repair is an important pathway for the protection of DNA molecules from destruction. DNA damage can be produced by oxidative reactive nitrogen or oxygen species, irritation, alkylating agents, depurination and depyrimidination; in this regard, DNA repair pathways can neutralize the negative effects of these factors. Melatonin is a hormone secreted from the pineal gland with an antioxidant effect by binding to oxidative factors. In addition, the effect of melatonin on DNA repair pathways has been proven by the literature. DNA repair is carried out by several mechanisms, of which homologous recombination repair (HRR) and non-homologous end-joining (NHEJ) are of great importance. Because of the importance of DNA repair in DNA integrity and the anticancer effect of this pathway, we presented the effect of melatonin on DNA repair factors regarding previous studies conducted in this area. © 2021 John Wiley & Sons Ltd
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