The Role Of The Gut Microbiota and Nutrition on Spatial Learning and Spatial Memory: A Mini Review Based on Animal Studies Publisher Pubmed



Alemohammad SMA¹ ; Noori SMR² ; Samarbafzadeh E³ ; Noori SMA^{4, 5}
Source: Molecular Biology Reports Published:2022

Abstract

The gut-brain axis is believed to constitute a bidirectional communication mechanism that affects both mental and digestive processes. Recently, the role of the gut microbiota in cognitive performance has been the focus of much research. In this paper, we discuss the effects of gut microbiota and nutrition on spatial memory and learning. Studies have shown the influence of diet on cognitive capabilities such as spatial learning and memory. It has been reported that a high-fat diet can alter gut microbiota which subsequently leads to changes in spatial learning and memory. Some microorganisms in the gut that can significantly affect spatial learning and memory are Akkermansia muciniphila, Bifidobacterium, Lactobacillus, Firmicutes, Bacteroidetes, and Helicobacter pylori. For example, a reduction in the amount of A. muciniphila in the gut leads to increased intestinal permeability and induces immune response in the brain which then negatively affects cognitive performances. We suggest that more studies should be carried out regarding the indirect effects of nutrition on cognitive activities via alteration in gut microbiota. © 2021, The Author(s), under exclusive licence to Springer Nature B.V.