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Simple, Green and One Pot New Strategy for Synthesis of the Phthalimide Derivatives Publisher



Gholami F2 ; Moazzam A1 ; Hosseini S1 ; Larijani B1 ; Adib M2 ; Mahdavi M1
Authors
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Centre, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Chemistry, College of Science, University of Tehran, Tehran, Iran

Source: Tetrahedron Letters Published:2022


Abstract

A novel, simple, green, one pot and practical synthetic method is described for the preparation of phthalimide derivatives through a condensation reaction between of 2-formylbenzoic acid and aniline in the presence of Et3N as base and S8 (Octasulfur) as oxidant in solvent free condition. This one-pot protocol provides these valuable desired compounds under mild conditions with excellent efficiency by using simple available starting materials. © 2022 Elsevier Ltd