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Simple, Green and One Pot New Strategy for Synthesis of the Phthalimide Derivatives Publisher



Gholami F2 ; Moazzam A1 ; Hosseini S1 ; Larijani B1 ; Adib M2 ; Mahdavi M1
Authors

Source: Tetrahedron Letters Published:2022


Abstract

A novel, simple, green, one pot and practical synthetic method is described for the preparation of phthalimide derivatives through a condensation reaction between of 2-formylbenzoic acid and aniline in the presence of Et3N as base and S8 (Octasulfur) as oxidant in solvent free condition. This one-pot protocol provides these valuable desired compounds under mild conditions with excellent efficiency by using simple available starting materials. © 2022 Elsevier Ltd