Tehran University of Medical Sciences

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Analysis of Associated Abnormalities and Outcome Assessment in Malformations of the Corpus Callosum Diagnosed Via Fetal Mri: A Cross-Sectional Study Publisher



Moradi B1, 2 ; Nikkhah A3 ; Kazemi MA1, 4 ; Gargari SS5 ; Shirazi M6 ; Nikkhah V3
Authors
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Authors Affiliations
  1. 1. Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Radiology, Yas Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Radiology, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Gynecology and Obstetrics, Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Maternal, Fetal and Neonatal Research Center, Yas Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Clinical Ultrasound Published:2025


Abstract

Background: The study explores corpus callosum malformation (CCM) using comprehensive brain Magnetic Resonance Imaging (MRI) for the assessment of associated malformations and their relation to long-term outcomes. Methods: During a 7-year period, all cases of CCM diagnosed via fetal MRI were retrospectively studied. Neurodevelopmental outcomes were assessed through postnatal interviews. Fetal brain imaging was performed using a 1.5-T MRI scanner without sedation, focusing on CC development and associated anomalies. Results: The study included 59 participants with CCM. Isolated CCM was observed in 25.4% of cases, while 74.6% presented with additional intracranial abnormalities, including cortical malformation (45.8%), periventricular nodular heterotopia (25.4%), supratentorial parenchymal signal intensity abnormality (25.4%), and sulcation delay (16.9%). Additionally, 16.9% of CCM cases were associated with non-neurological anomalies, such as craniofacial malformations (8.5%) and urinary abnormalities (5.1%). In terms of pregnancy outcomes, 20.3% underwent pregnancy termination, 5.1% ended in stillbirth, 22.0% resulted in death after birth, and 52.5% resulted in live births. A significant association was observed between the coexistence of cortical malformation and poor prognosis (p = 0. 012). Conclusion: The broad spectrum of anomalies linked to CCM, along with their clinical outcomes, underscores the pivotal role of MRI in prenatal screening for fetuses diagnosed with CCM. © 2025 Wiley Periodicals LLC.