Smoking and Brain Neoplasm: An Immunohistochemical Data Evaluating Caspase-3 and Mmp-2 in Rat Brain

Smoking and Brain Neoplasm: An Immunohistochemical Data Evaluating Caspase-3 and Mmp-2 in Rat Brain Publisher

Mortazavi SA¹ ; Digaleh H¹ ; Saffar H² ; Ebrahimi H¹ ; Kazemi H¹ ; Madreseh E³

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1. Department of Neurosurgery, Sina Hospital, Tehran, Iran
2. Department of Pathology, Shariati Hospital, Tehran, Iran
3. Department of Epidemiology and Biostatistics, School of Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Neurosurgery Published:2023

Abstract

Background and Aim: Smoking has been extensively investigated in oncology, and controversial associations with brain tumor incidence have been reported. Caspase-3 and matrix metalloproteinases (MMPs) belong to an important cascade in tumor vasculogenesis. We aim to study the smoking impact on these signaling molecules in nontumoral rat brain tissue. Methods and Materials/Patients: A total of 60 Wistar rats were divided into two groups: treatment (cigarette smoke/electronic cigarette) and control groups with subgroups of male and female rats. After general anesthesia and decapitation, their brains were collected, and 3-μm thick coronal sections were prepared. Following immunohistochemical staining with rabbit anti-MMP-2 and anti-caspase-3 antigens, protein expressions were analyzed by selecting two fields at 400x magnification. Results: Our data suggest that the expression of MMP-2 was not significantly different between the studied groups. However, the significant inductive activity of cigarette smoking was observed on caspase-3. Conclusion: Cigarette smoking indicates pro-tumoral signaling impact in normal tissue with activation of caspase-3 in rat brain tissue. © 2023 Guilan University of Medical Sciences.

Style	Citing Format
MLA	Mortazavi SA, et al.. "Smoking and Brain Neoplasm: An Immunohistochemical Data Evaluating Caspase-3 and Mmp-2 in Rat Brain." Iranian Journal of Neurosurgery, vol. 9, no. , 2023, pp. -.
APA	Mortazavi SA, Digaleh H, Saffar H, Ebrahimi H, Kazemi H, Madreseh E (2023). Smoking and Brain Neoplasm: An Immunohistochemical Data Evaluating Caspase-3 and Mmp-2 in Rat Brain. Iranian Journal of Neurosurgery, 9(), -.
Chicago	Mortazavi SA, Digaleh H, Saffar H, Ebrahimi H, Kazemi H, Madreseh E. "Smoking and Brain Neoplasm: An Immunohistochemical Data Evaluating Caspase-3 and Mmp-2 in Rat Brain." Iranian Journal of Neurosurgery 9, no. (2023): -.
Harvard	Mortazavi SA et al. (2023) 'Smoking and Brain Neoplasm: An Immunohistochemical Data Evaluating Caspase-3 and Mmp-2 in Rat Brain', Iranian Journal of Neurosurgery, 9(), pp. -.
Vancouver	Mortazavi SA, Digaleh H, Saffar H, Ebrahimi H, Kazemi H, Madreseh E. Smoking and Brain Neoplasm: An Immunohistochemical Data Evaluating Caspase-3 and Mmp-2 in Rat Brain. Iranian Journal of Neurosurgery. 2023;9():-.
BibTex	@article{ author = {Mortazavi SA and Digaleh H and Saffar H and Ebrahimi H and Kazemi H and Madreseh E}, title = {Smoking and Brain Neoplasm: An Immunohistochemical Data Evaluating Caspase-3 and Mmp-2 in Rat Brain}, journal = {Iranian Journal of Neurosurgery}, volume = {9}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Mortazavi SA AU - Digaleh H AU - Saffar H AU - Ebrahimi H AU - Kazemi H AU - Madreseh E TI - Smoking and Brain Neoplasm: An Immunohistochemical Data Evaluating Caspase-3 and Mmp-2 in Rat Brain JO - Iranian Journal of Neurosurgery VL - 9 IS - SP - EP - PY - 2023 ER -

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