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Molecular Analysis of Radiation Resistance Process in Radioresistant Oesophageal Adenocarcinoma Cells Publisher



Arjmand B1, 2 ; Rezaeitavirani M3 ; Hamzeloomoghadam M4 ; Razzaghi Z5 ; Rezaeitavirani M3
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Authors Affiliations
  1. 1. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Iranian Cancer Control Center (MACSA), Tehran, Iran
  3. 3. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Traditional Pharmacy, Traditional Medicine and Materia Medica Research Center, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Surgery, Firouzabadi Hospital, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: International Journal of Cancer Management Published:2023


Abstract

Background: The radiation resistance process is a major problem in radiotherapy. Proteomics is a useful method to determine the molecular mechanism of biological and medical events. Protein-protein interaction (PPI) network is a suitable method for proteomics data interpretation. Objectives: Assessment of proteomics data about the radiation resistance process in human cell lines via PPI network analysis is the aim of this study. Methods: Proteomic data were extracted from literature and the differentially expressed proteins (DEPs) were included in the PPI network via the STRING database by Cytoscape software. The network was analyzed and the central nodes were introduced. The central nodes were assessed via action map analysis and gene ontology enrichment. Results: Among the 251 queried DEPs, 171 individuals were included in the PPI network. Epidermal growth factor receptor (EGFR), fibronectin (FN1), CD44 antigen (CD44), prostaglandin G/H synthase 2 (PTGS2), CD44 antigen (CD44), prostaglandin G/H synthase 2 (PTGS2), NF-kappa-B inhibitor alpha (NFKBIA), Kelch-like ECH-associated protein 1 (KEAP1), cathepsin D (CTSD), D-3-phosphoglycerate dehydrogenase (PHGD), and 5-nucleotidase (NT5E) were introduced as the critical DEPs. Eight groups of biological terms were attributed to the introduced critical DEPs. EGFR, FN1, CD44, and PTGS2 were discriminated among the critical DEPs as the key dysregulated proteins. Conclusions: The results indicate that EGFR, FN1, CD44, and PTGS2 are the four essential proteins that are involved in radiation resistance in the radioresistant cells. © 2023, Author(s).
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