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Cell-Based Approaches Towards Treating Age-Related Macular Degeneration Publisher Pubmed



Baradaranrafii A1, 2 ; Sarvari M3 ; Alavimoghadam S3 ; Payab M4 ; Goodarzi P5 ; Aghayan HR3 ; Larijani B6 ; Rezaeitavirani M7 ; Biglar M6 ; Arjmand B3, 8
Authors
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Authors Affiliations
  1. 1. Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Cell and Tissue Banking Published:2020


Abstract

Age-related macular degeneration as one of the most common causes of worldwide vision loss needs a proper approach for treatment. Therein, cell therapy and regenerative medicine can hold a great promise to be an effective approach. Accordingly, some preclinical and clinical studies were conducted to search around the therapeutic influence of stem cells in Age-related macular degeneration models and subjects. Hereupon, the purpose of the current review is to discuss the mechanisms of age-related macular degeneration, appropriate animal models along with suitable dosage and route of stem cell administration for its treatment. © 2020, Springer Nature B.V.
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