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Comparison of Four Surgical Techniques for Management of Pseudophakic and Aphakic Retinal Detachment: A Multicenter Clinical Trial Publisher Pubmed



Moradian S1 ; Ahmadieh H2 ; Faghihi H3 ; Ramezani A2 ; Entezari M2 ; Banaee T4 ; Heidari E5 ; Behboudi H6 ; Yasseri M2, 7
Authors
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Authors Affiliations
  1. 1. Ophthalmic Epidemiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Pasdaran Ave. Boostan 9 St., Tehran, 16666, Iran
  3. 3. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Retina Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Nikookari Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Eye Research Center, Amiralmomenin Hospital, Guilan University of Medical Sciences, Rasht, Iran
  7. 7. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Graefe's Archive for Clinical and Experimental Ophthalmology Published:2016


Abstract

Purpose: To compare the visual and anatomical outcomes of four surgical techniques to manage pseudophakic and aphakic retinal detachment (PARD). Methods: In a multicenter randomized clinical trial, 211 eyes of 211 patients with PARD and proliferative vitreoretinopathy (PVR) grade B or less were randomly assigned to one of the four treatment groups: (1) scleral buckling (SB), 50 eyes, (2) vitrectomy without band, 51 eyes, (3) vitrectomy with encircling band (EB), 58 eyes, and (4) triamcinolone acetonide (TA) assisted vitrectomy, 52 eyes. Patients were followed for 12 months after the surgery. The best-corrected visual acuity (BCVA) and retinal reattachment rate at each follow-up time point were considered as the primary outcome measures. PVR, macular pucker, and cystoid macular edema were considered as the secondary outcomes. Results: Visual improvement was achieved in all treatment groups relative to the baseline at all time points (all Ps < 0.001). There were no statistically significant differences among the groups with regard to BCVA changes. However, there was a significant difference in the slope of visual improvement curve: the SB group had a more rapid visual improvement compared to the vitrectomy with buckle group at month 12 (P = 0.032). The retinal reattachment rates at month 12 were 75, 64.7, 68.5, and 66.7 % in SB, vitrectomy without buckle, vitrectomy with EB, and TA-assisted vitrectomy groups respectively (P > 0.99). There were no statistically significant differences among the groups in terms of adverse events. Conclusions: SB, TA-assisted vitrectomy, and vitrectomy with and without buckle had comparable outcomes in the management of PARD. © 2016, Springer-Verlag Berlin Heidelberg.
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