Effect of Topical Administration of Tranexamic Acid on Intraoperative and Postoperative Blood Loss During Posterior Cervical Laminectomy and Fusion Surgery: A Retrospective Study

Effect of Topical Administration of Tranexamic Acid on Intraoperative and Postoperative Blood Loss During Posterior Cervical Laminectomy and Fusion Surgery: A Retrospective Study Publisher Pubmed

Khadivi M^{1, 2, 3} ; Saghebdoust S^{1, 4} ; Moghadam N^{1, 3} ; Zarei M⁵ ; Moosavi M³ ; Ataei H⁶ ; Jafarieh A⁷ ; Borghei A⁸ ; Shafizadeh M² ; Eslamian M² ; Jouibari MF² ; Kordi R¹ ; Rostami M³

Show Affiliations

1. Tehran University of Medical Sciences, Neuroscience Institute, Sports Medicine Research Center, Tehran, Iran
2. Tehran University of Medical Sciences, Shariati Hospital, Department of Neurosurgery, Tehran, Iran
3. Tehran University of Medical Sciences, Spine Center of Excellence, Yas Hospital, Tehran, Iran
4. Razavi Hospital, Department of Neurosurgery, Mashhad, Iran
5. Tehran University of Medical Sciences, Imam Hospital, Department of Orthopedics, Tehran, Iran
6. Tehran University of Medical Sciences, Yas Hospital, Department of Anesthesiology, Tehran, Iran
7. Tehran University of Medical Sciences, Amiralam Hospital, Department of Anesthesiology, Tehran, Iran
8. Rush University Medical Center, Department of Neurosurgery, Chicago, IL, United States

Source: Turkish Neurosurgery Published:2023

Abstract

AIM: To assess the role of topical administration of tranexamic acid (TXA) on intraoperative and postoperative blood loss of patients undergoing posterior cervical laminectomy and lateral mass screw fixation (PCLF) compared to a control group. MATERIAL and METHODS: The data of 88 patients that underwent PCLF surgery, including 41 females and 47 males, were included in this retrospective study. Data elements including intraoperative blood loss (IBL), postoperative blood loss (PBL), amount of blood transfusion, surgical time, use of hemostatic agents, length of hospital stay, and time to return to work were extracted from medical records and compared between those who received topical TXA during surgery (irrigation of the surgical field with a solution of 3 g TXA in 100 ml normal saline) and an age and sex-matched control group. RESULTS: There were 48 patients in the TXA group and 40 patients in the control group. There were no significant differences in the baseline measurements and the level of operation between the two groups. The results showed that IBL and PBL were significantly lower in the TXA group compared to the control group (p=0.03 and p<0.01, respectively). There were no significant differences in the need for blood transfusion, surgical time, and hospital stay between the two groups (p>0.05). Moreover, the use of hemostatic materials during surgery and the time to return to work were significantly lower in the topical TXA group (p=0.04 and p<0.01, respectively). CONCLUSION: Topical TXA efficiently reduces intraoperative and postoperative bleeding in patients undergoing posterior cervical laminectomy and PCLF surgery. These results need further investigation in future studies to draw a definite conclusion. © 2023 Turkish Neurosurgery. All Rights Reserved.

Experts (# of related papers)

Masoud Khadivi (1)

Style	Citing Format
MLA	Khadivi M, et al.. "Effect of Topical Administration of Tranexamic Acid on Intraoperative and Postoperative Blood Loss During Posterior Cervical Laminectomy and Fusion Surgery: A Retrospective Study." Turkish Neurosurgery, vol. 33, no. 1, 2023, pp. 94-100.
APA	Khadivi M, Saghebdoust S, Moghadam N, Zarei M, Moosavi M, Ataei H, Jafarieh A, Borghei A, Shafizadeh M, Eslamian M, Jouibari MF, Kordi R, Rostami M (2023). Effect of Topical Administration of Tranexamic Acid on Intraoperative and Postoperative Blood Loss During Posterior Cervical Laminectomy and Fusion Surgery: A Retrospective Study. Turkish Neurosurgery, 33(1), 94-100.
Chicago	Khadivi M, Saghebdoust S, Moghadam N, Zarei M, Moosavi M, Ataei H, Jafarieh A, et al.. "Effect of Topical Administration of Tranexamic Acid on Intraoperative and Postoperative Blood Loss During Posterior Cervical Laminectomy and Fusion Surgery: A Retrospective Study." Turkish Neurosurgery 33, no. 1 (2023): 94-100.
Harvard	Khadivi M et al. (2023) 'Effect of Topical Administration of Tranexamic Acid on Intraoperative and Postoperative Blood Loss During Posterior Cervical Laminectomy and Fusion Surgery: A Retrospective Study', Turkish Neurosurgery, 33(1), pp. 94-100.
Vancouver	Khadivi M, Saghebdoust S, Moghadam N, Zarei M, Moosavi M, Ataei H, et al.. Effect of Topical Administration of Tranexamic Acid on Intraoperative and Postoperative Blood Loss During Posterior Cervical Laminectomy and Fusion Surgery: A Retrospective Study. Turkish Neurosurgery. 2023;33(1):94-100.
BibTex	@article{ author = {Khadivi M and Saghebdoust S and Moghadam N and Zarei M and Moosavi M and Ataei H and Jafarieh A and Borghei A and Shafizadeh M and Eslamian M and Jouibari MF and Kordi R and Rostami M}, title = {Effect of Topical Administration of Tranexamic Acid on Intraoperative and Postoperative Blood Loss During Posterior Cervical Laminectomy and Fusion Surgery: A Retrospective Study}, journal = {Turkish Neurosurgery}, volume = {33}, number = {1}, pages = {94-100}, year = {2023} }
RIS	TY - JOUR AU - Khadivi M AU - Saghebdoust S AU - Moghadam N AU - Zarei M AU - Moosavi M AU - Ataei H AU - Jafarieh A AU - Borghei A AU - Shafizadeh M AU - Eslamian M AU - Jouibari MF AU - Kordi R AU - Rostami M TI - Effect of Topical Administration of Tranexamic Acid on Intraoperative and Postoperative Blood Loss During Posterior Cervical Laminectomy and Fusion Surgery: A Retrospective Study JO - Turkish Neurosurgery VL - 33 IS - 1 SP - 94 EP - 100 PY - 2023 ER -

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