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The Role of Inflammatory Cytokines and Tumor Associated Macrophages (Tams) in Microenvironment of Pancreatic Cancer Publisher Pubmed



Farajzadeh Valilou S1 ; Keshavarzfathi M1, 2, 3 ; Silvestris N4, 6 ; Argentiero A5, 6 ; Rezaei N3, 7, 8
Authors
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Authors Affiliations
  1. 1. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  2. 2. Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Medical Oncology Unit and Scientific Directorate, National Cancer Institute IRCCS “Giovanni Paolo II�, Bari, Italy
  5. 5. Medical Oncology Unit, National Cancer Institute IRCCS “Giovanni Paolo II�, Bari, Italy
  6. 6. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Bari, Italy
  7. 7. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Sheffield, United Kingdom

Source: Cytokine and Growth Factor Reviews Published:2018


Abstract

Pancreatic cancer is considered as one of the most lethal types of cancer due to its poor prognosis and lack of effective therapeutic approaches. Although many studies have been done on pancreatic cancer, the current treatment methods did not exhibit successful results. Hence, novel strategies are needed for treatment of pancreatic cancer. The microenvironment of pancreatic cancer contains many factors such as inflammatory cytokines and tumor associated macrophages (TAMs), which influence the tumor's status. These factors can be upregulated and consequently lead to exacerbation of tumor progression. Understanding the role of pro- and anti-inflammatory cytokines and the function of TAMs in the pancreatic cancer microenvironment might lead to development and improvement of novel strategies in the diagnosis and treatment of pancreatic cancer and may result in promising treatments for this type of cancer. © 2018 Elsevier Ltd
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