Prognostic Value of Platelet to Lymphocyte Ratio in Sepsis: A Systematic Review and Meta-Analysis Publisher Pubmed



Wang G¹ ; Mivefroshan A² ; Yaghoobpoor S³ ; Khanzadeh S⁴ ; Siri G⁵ ; Rahmani F⁶ ; Aleseidi S⁷
Source: BioMed Research International Published:2022

Abstract

The goal of this study was to conduct a systematic review of the literature on the relationship between peripheral blood platelet to lymphocyte ratio (PLR) and mortality in sepsis and to integrate the findings in a meta-analysis. An electronic search of three main databases was performed: PubMed, Embase, and Scopus on 19 December 2021. Finally, 16 studies comprising 2403 septic patients, including 1249 survivors and 1154 nonsurvivors, were included in this meta-analysis. We found that PLR levels were significantly higher in nonsurvivors than in survivors (random effect model: SMD=0.72, 95% CI; 0.35-1.10, p<0.001). However, significant heterogeneity was observed across the studies (I2=94.1%, p<0.01). So, we used random effect model in our meta-analysis. In the subgroup analysis, according to mortality time, patients deceased during one month after sepsis had elevated levels of PLR compared to survivors (SMD=1.03, 95% CI=0.15-1.92, p=0.22). However, in-hospital mortality was not associated with PLR level (SMD=0.41, 95% CI=-0.18-0.99, p=0.175). Our findings support PLR to be a promising biomarker that can be readily integrated into clinical settings to aid in the prediction and prevention of sepsis mortality. © 2022 Gancheng Wang et al.