Evaluation of a Novel Natural Drop for Treatment of Chronic Rhinosinusitis Without Nasal Polyps: A Single Blind Randomized Trial Publisher Pubmed



Vazifehkah S¹ ; Shamsardekani MR² ; Kamalinejad M³ ; Saderhossein SM⁴ ; Hosseini H⁵ ; Shams SM⁶ ; Abbassi S⁷ ; Eghtesad S⁸ ; Saedi B⁴ Show Affiliations
Source: International Forum of Allergy and Rhinology Published:2016

Abstract

Background: The present study investigated the effectiveness of a Pimpinella anisum–based herbal medicine for treating chronic rhinosinusitis (CRS) without polyps in comparison to fluticasone nasal spray, in a single-blinded randomized trial. Methods: Patients with CRS without nasal polyps were randomly assigned into 2 treatment groups: individuals in the first group (n = 26) received 2 drops of a P. anisum–based herbal medicine (Sinupim) in each nostril every 12 hours, while those in the second group (n = 22) received 2 puffs of fluticasone nasal spray in each nostril every 12 hours. Both groups used their designated treatments for 4 weeks. Patients were evaluated by the 22-item Sino-Nasal Outcome Test (SNOT-22) at the start of the trial and after the completion of their treatment. Results: Although both treatments were effective in reducing patients’ symptoms, there were significantly better results in the Sinupim group based on the SNOT-22 evaluation. Mean changes in computed tomography (CT) scan scoring in Sinupim and fluticasone groups before and after treatment were 2.22 ± 2.94 and 0.76 ± 1.39, respectively, which was significant within both groups (p < 0.05). Postnasal drip and nasal obstruction were more significantly improved in the Sinupim group. Conclusion: A P. anisum–based herbal medicine may be an effective treatment for sinusitis without polyps. However, its wide acceptance needs further investigation. © 2016 ARS-AAOA, LLC