Retinal Vascular Abnormalities in Different Types of Inherited Retinal Dystrophies Assessed by Optical Coherence Tomography Angiography

Retinal Vascular Abnormalities in Different Types of Inherited Retinal Dystrophies Assessed by Optical Coherence Tomography Angiography Publisher

Sabbaghi H^{1, 2} ; Daftarian N³ ; Hassanpour K⁴ ; Fekri S⁴ ; Nourinia R⁴ ; Suri F⁴ ; Kheiri B⁴ ; Yaseri M⁵ ; Rajabpour M² ; Sheibani K⁶ ; Ahmadieh H⁴

Show Affiliations

1. Ophthalmic Epidemiology Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Optometry, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Ocular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran
6. Basir Eye Health Research Center, Tehran, Iran

Source: Journal of Current Ophthalmology Published:2021

Abstract

Purpose: To investigate the retinal vascular characteristics among patients with different types of inherited retinal dystrophies (IRDs). Methods: This comparative cross-sectional study was conducted on 59 genetically confirmed cases of IRD including 37 patients with retinitis pigmentosa (RP) (74 eyes), 13 patients with Stargardt disease (STGD) (26 eyes), and 9 patients with cone-rod dystrophy (CRD) (18 eyes). Both eyes of 50 age-and sex-matched healthy individuals were investigated as controls. All participants underwent optical coherence tomography angiography to investigate the vascular densities (VDs) of superficial and deep capillary plexus (SCP and DCP) as well as foveal avascular zone area. Results: In RP, significantly lower VD in whole image (P = 0.001 for DCP), fovea (P = 0.038 for SCP), parafovea (P < 0.001 for SCP and DCP), and perifovea (P < 0.001 for SCP and DCP) was observed compared to controls. In STGD, VD of parafovea (P = 0.012 for SCP and P = 0.001 for DCP) and fovea (P = 0.016 for DCP) was significantly lower than controls. In CRD, the VD of parafovea (P = 0.025 for DCP) was significantly lower than controls. Whole image density was significantly lower in RP compared to STGD (P < 0.001 for SCP) and CRD (P = 0.037 for SCP). VD in parafovea (P = 0.005 for SCP) and perifovea (P < 0.001 for SCP and DCP) regions was significantly lower in RP compared with STGD. Also, foveal VD in STGD was significantly lower than RP (P = 0.023 for DCP). Conclusion: Our study demonstrated lower VDs in three different IRDs including RP, STGD, and CRD compared to healthy controls. Changes were more dominant in RP patients. © 2021 Journal of Current Ophthalmology Published by Wolters Kluwer-Medknow.

Related Docs

1. Spatial Distribution of Diabetic Capillary Non-Perfusion, Microcirculation (2021)

2. Choroidal Thickness in Different Types of Inherited Retinal Dystrophies, Journal of Ophthalmic and Vision Research (2020)

3. Cataract Surgery in Patients With Retinitis Pigmentosa: Systematic Review, Journal of Cataract and Refractive Surgery (2023)

Experts (# of related papers)

View all Related Experts

Hamid Riazi-Esfahani (2)

Elias Khalilipour (1)

Style	Citing Format
MLA	Sabbaghi H, et al.. "Retinal Vascular Abnormalities in Different Types of Inherited Retinal Dystrophies Assessed by Optical Coherence Tomography Angiography." Journal of Current Ophthalmology, vol. 33, no. 2, 2021, pp. 189-196.
APA	Sabbaghi H, Daftarian N, Hassanpour K, Fekri S, Nourinia R, Suri F, Kheiri B, Yaseri M, Rajabpour M, Sheibani K, Ahmadieh H (2021). Retinal Vascular Abnormalities in Different Types of Inherited Retinal Dystrophies Assessed by Optical Coherence Tomography Angiography. Journal of Current Ophthalmology, 33(2), 189-196.
Chicago	Sabbaghi H, Daftarian N, Hassanpour K, Fekri S, Nourinia R, Suri F, Kheiri B, et al.. "Retinal Vascular Abnormalities in Different Types of Inherited Retinal Dystrophies Assessed by Optical Coherence Tomography Angiography." Journal of Current Ophthalmology 33, no. 2 (2021): 189-196.
Harvard	Sabbaghi H et al. (2021) 'Retinal Vascular Abnormalities in Different Types of Inherited Retinal Dystrophies Assessed by Optical Coherence Tomography Angiography', Journal of Current Ophthalmology, 33(2), pp. 189-196.
Vancouver	Sabbaghi H, Daftarian N, Hassanpour K, Fekri S, Nourinia R, Suri F, et al.. Retinal Vascular Abnormalities in Different Types of Inherited Retinal Dystrophies Assessed by Optical Coherence Tomography Angiography. Journal of Current Ophthalmology. 2021;33(2):189-196.
BibTex	@article{ author = {Sabbaghi H and Daftarian N and Hassanpour K and Fekri S and Nourinia R and Suri F and Kheiri B and Yaseri M and Rajabpour M and Sheibani K and Ahmadieh H}, title = {Retinal Vascular Abnormalities in Different Types of Inherited Retinal Dystrophies Assessed by Optical Coherence Tomography Angiography}, journal = {Journal of Current Ophthalmology}, volume = {33}, number = {2}, pages = {189-196}, year = {2021} }
RIS	TY - JOUR AU - Sabbaghi H AU - Daftarian N AU - Hassanpour K AU - Fekri S AU - Nourinia R AU - Suri F AU - Kheiri B AU - Yaseri M AU - Rajabpour M AU - Sheibani K AU - Ahmadieh H TI - Retinal Vascular Abnormalities in Different Types of Inherited Retinal Dystrophies Assessed by Optical Coherence Tomography Angiography JO - Journal of Current Ophthalmology VL - 33 IS - 2 SP - 189 EP - 196 PY - 2021 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract