Comparison of Effectiveness and Safety of Labetalol and Hydralazine on Blood Pressure During Cataract Surgery in Patients With Hypertension



Espahbodi E¹ ; Takzare A¹ ; Sanatkar M¹ ; Goudarzi M¹ Show Affiliations
Source: Revista Latinoamericana de Hipertension Published:2019

Abstract

Introduction: Cataract surgery is one of the most commonly performed surgeries, and patients over the age of 60 are major candidates for this procedure. Hypertension is one of the most commonly reported diseases in this age group. Since hypertension is associated with poor surgery outcomes, it is important to find appropriate medications for controlling the optimal blood pressure of patients. Therefore, the present study aimed to compare the effect of labetalol and hydralazine on blood pressure during cataract surgery. Materials and Methods: A total of 63 patients undergoing cataract surgery in 2014-2015 were enrolled in this clinical trial, and randomly assigned to the hydralazine group (n=30) and the labetalol group (n=33). Systolic, diastolic, and mean arterial blood pressure and heart rate were recorded at 0, 5, 10, and 15 minutes. Findings: Changes in the heart rate were similar in both groups and had an increasing trend from baseline to 15 minutes. In terms of changes in blood pressure after drug injection, labetalol resulted in a more rapid decrease in systolic, diastolic, and mean arterial blood pressures than hydralazine, so that their values were significantly lower in the labetalol group than the hydralazine group after 5 minutes. Conclusion: Both labetalol and hydralazine seem to be suitable for controlling blood pressure during surgery. However, the more rapid effect of labetalol than hydralazine on lowering blood pressure and the reflex tachycardia, observed most often with hydralazine, should be considered when selecting them. © 2019 Revista Latinoamericana de Hipertension. All rights reserved.