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The Effect of Fibrin Glue on the Postoperative Lymphatic Leakage After D2-Lymphadenectomy and Gastrectomy in Patients With Gastric Cancer Publisher Pubmed



Mahmoodzadeh H1 ; Rahimimovaghar E2 ; Omranipour R1, 3 ; Shirkhoda M1 ; Jalaeefar A1 ; Miri SR1 ; Sharifi A4
Authors
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Authors Affiliations
  1. 1. Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Fellowship of Oncosurgery, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Breast Disease Research Center, Tehran university of Medical Sciences, Tehran, Iran
  4. 4. Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: BMC Surgery Published:2021


Abstract

Introduction: Disturbance in the lymphatic drainage during D2 dissection is associated with significant morbidity. We aimed to assess the effect of fibrin glue on the reduction of postoperative lymphatic leakage. Methods: Prospective double-blinded randomized clinical trial with forty patients in each study arm was conducted. All patients diagnosed, staged, and became a candidate for D2 dissection based on NCCN 2019 guideline for gastric cancer. The intervention group received 1 cc of IFABOND® applied to the surgical bed. Results: The difference between study groups regarding age, gender, tumor stage was insignificant. (All p-values > 0.05). The median daily drainage volume was 120 ml with the first and the third interquartile being 75 and 210 ml, respectively for the intervention group. The control group had median, the first, and the third interquartile of 350, 290, and 420 ml. The difference between daily drainage volumes was statistically significant (p-value < 0.001). The length of hospital stay was significantly different between the two groups. Notably, the intervention group was discharged sooner (median of 7 Vs 9 days, p-value: 0.001). Conclusion: This study showed the possible role of fibrin glue in reducing postoperative lymphatic leakage after gastrectomy and D2 dissection. Registration trial number: IRCT20200710048071N1, 2020.08.16. © 2021, The Author(s).