High-Density Lipoprotein Particles Are Associated With the Risk of Mortality From All-Causes and Cardiovascular Diseases (Cvds) in Patients With Cvd: A Systematic Review and Meta-Analysis Study Publisher Pubmed



E Sharifizahabi ELHAM ; N Nasiri NOOSHIN ; F Hajizadehsharafabad FATEMEH ; S Mohammadi SOBHAN ; S Shahbazi SHAGHAYEGH ; N Salehi NAHID
Source: Lipids in Health and Disease Published:2025

Abstract

Background & aims: Increasing data indicate that the concentration of high-density lipoprotein particles (HDL-p) may be a strong indicator of cardiovascular disease. This study aimed to carry out a meta-analysis to examine the link between subclasses of HDL-p and the hazard of mortality in individuals suffering from cardiovascular diseases (CVDs). Methods: A rigorous systematic search was executed through Scopus, PubMed, and Web of Science up to April 2025. Results: Seven unique cohort studies were deemed eligible for incorporation in this meta-analysis. The overall hazard was derived by applying a random effects model. The results indicated a negative association of total HDL-p (RR: 0.74, 95% CI: 0.69–0.78, P < 0.001) and small HDL-p with all-cause mortality (RR: 0.69, 95% CI: 0.63–0.75, P < 0.001) for each 5 µmol/l increment. Similarly, each 5 µmol/l large HDL-p was directly related to all-cause mortality (RR: 1.71, 95% CI: 1.14– 2.56; P = 0.009). Moreover, each 5 µmol/l increase in small HDL-p was linked to a 33% reduction in CVD mortality (RR: 0.67, 95% CI: 0.50–0.91; P = 0.01). Conclusion: This study revealed that small and total HDL-p were negatively correlated with all-cause mortality, whereas latge HDL-p was positively related to mortality from all causes. Additionally, small HDL-p had an inverse relationship with CVD mortality in patients with CVD. © 2025 Elsevier B.V., All rights reserved.