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Swimming Training Modulates Lung Injury Induced by Ovariectomy in Diabetic Rats: Involvement of Inflammatory and Fibrotic Biomarkers Publisher Pubmed



Daghigh F1, 2 ; Karimi P3 ; Alihemmati A4 ; Majidi Zolbin M5, 6 ; Ahmadiasl N2
Authors
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Authors Affiliations
  1. 1. Department of Physiology, Tabriz Branch, Islamic Azad University, Tabriz, Iran
  2. 2. Tuberculosis and Lung diseases research center, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Histology & Embryology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children's Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Archives of Physiology and Biochemistry Published:2022


Abstract

Context: Previous studies have noted that the incidence of inflammatory and fibrotic diseases is higher in diabetic menopausal women. Objective: In the present study, we evaluated effects of swimming training on inflammatory and fibrotic biomarkers in the lung of ovariectomized diabetic rats. Materials and methods: Forty female rats were assigned into four groups: sham; rats underwent surgery without ovariectomies, OVX: rats that underwent ovariectomies, OVX.Dia: ovariectomized rats with high-fat diet, OVX.Dia. Exe: ovariectomized diabetic rats with 8 weeks of swimming training. At the end of experiment, protein expressions were assessed with western blot. Lung sections were subjected to immunohistochemical and haematoxylin eosin staining. Results: There was a significant difference in the protein expressions between exercise and ovariectomized diabetic groups (p <.05). Conclusion: The present study showed strong potential of swimming training on oestrogen deficient diabetic lung. These data encourage further investigation into the inclusive effects of exercise in menopausal diabetic women. © 2019 Informa UK Limited, trading as Taylor & Francis Group.
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