Tehran University of Medical Sciences

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Allylamine Publisher



Salarinejad S1 ; Foroumadi A1, 2
Authors
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Authors Affiliations
  1. 1. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran

Source: Encyclopedia of Toxicology# Fourth Edition: Volume 1-9 Published:2023


Abstract

Allylamine as a primary unsaturated alkylamine is a colorless volatile liquid with a very sharp odor resembling ammonia. This flammable and oxidizable substance are generally utilized in the pharmaceutical industry and vulcanization of rubber. Mainly owing to the alkaline character of allylamine, it is considered a severe irritant for the respiratory, eye, skin, and above all cardiovascular system when after human exposure, whether orally, by injection, or by inhalation at high doses. Scientific evidence reveals that the two metabolites, acrolein, and hydrogen peroxide, induce cardiac side effects. Heart failure, lung failure, or a combination can be lethal. © 2024 Elsevier Inc. All rights reserved.