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Circulating Resistin and Follistatin Levels in Obese and Non-Obese Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis Publisher Pubmed



Raeisi T1 ; Rezaie H2 ; Darand M3 ; Taheri A4 ; Garousi N5 ; Razi B6 ; Roever L7 ; Mohseni R8 ; Mohammed SH9 ; Alizadeh S8
Authors
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Authors Affiliations
  1. 1. Department of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  2. 2. Department of Anatomy, School of Medicine Tehran University of Medical Sciences, Tehran, Iran
  3. 3. National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Science and Research Branch, Faculty of Medicine, Islamic Azad University, Tehran, Iran
  5. 5. Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Hematology and Blood Banking, School of Allied Medical Sciences, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  7. 7. Department of Clinical Research, Federal University of Uberlandia, Minas Gerais, Brazil
  8. 8. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences-International Campus (TUMS-IC), Tehran, Iran

Source: PLoS ONE Published:2021


Abstract

This meta-analysis was performed to resolve the inconsistencies regarding resistin and follistatin levels in women with polycystic ovary syndrome (PCOS) by pooling the available evidence. A systematic literature search using PubMed and Scopus was carried out through November 2020 to obtain all pertinent studies. Weighted mean differences (WMDs) with corresponding 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between the levels of resistin and follistatin with PCOS in the overall and stratified analysis by obesity status. A total of 47 publications, 38 for resistin (2424 cases; 1906 controls) and 9 studies for follistatin (815 cases; 328 controls), were included in the meta-analysis. Resistin levels were significantly higher in PCOS women compared with non-PCOS controls (WMD = 1.96 ng/ml; 95%CI = 1.25-2.67, P?0.001) as well as in obese PCOS women vs. obese controls, and in non-obese PCOS women compared with non-obese controls, but not in obese PCOS vs. non-obese PCOS patients,. A significantly increased circulating follistatin was found in PCOS patients compared with the controls (WMD = 0.44 ng/ml; 95%CI = 0.30-0.58, P?0.001) and in non-obese PCOS women compared with non-obese controls and in obese PCOS women vs. obese controls, but, no significant difference in follistatin level was observed in obese PCOS compared with non-obese PCOS women. Significant heterogeneity and publication bias was evident for some analyses. Circulating levels of resistin and follistatin, independent of obesity status, are higher in women with PCOS compared with controls, showing that these adipokines may contribute to the pathology of PCOS. © 2021 Public Library of Science. All rights reserved.
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