Nanocomposite-Coated Sterile Cotton Gas Based on Polylactic Acid and Nanoparticles (Zinc Oxide and Copper Oxide) and Tranexamic Acid Drug With the Aim of Wound Dressing Publisher



Molapour Rashedi S¹ ; Khajavi R² ; Rashidi A¹ ; Rahimi M³ ; Bahador A⁴ Show Affiliations
Source: Regenerative Engineering and Translational Medicine Published:2021

Abstract

Abstract: Nanofibers and nanoparticles have found significant performance in controlled drug release among various nanostructures due to their high surface area and excellent biocompatibility. Metal oxide nanoparticles have shown antimicrobial activities against a wide range of microorganisms. Tranexamic acid has also been used in various forms to prevent bleeding. In this research, PLA/NPs/TXA composite nanofibers were prepared by electrospinning method. The morphology and size of the nanoparticles and the active chemical functional groups of composite were evaluated using Fourier transform-infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and X-ray energy dispersive spectroscopy (EDS). An antimicrobial test was performed on Staphylococcus aureus and Escherichia coli. The final morphology of nanofibers showed that the nanocomposite coating resulted in a smaller diameter compared to the pure polymer coating. Examining the microbial properties of zinc and copper oxides revealed that these compounds could inhibit the growth of bacteria through binding to cell membranes and even penetration, which can finally lead to the death of bacterial cells. The inhibition zone diameter increased by enhancing the concentration of nanoparticles, especially in the case of Escherichia coli. The results show the high performance of sterile gauze coated by the nanocomposite containing effective nanoparticles and tranexamic acid. Lay Summary: Antimicrobial effects can inhibit pathogenic bacteria growth. Nanoparticles prevent the formation of defense agents in these microorganisms against the host immune system. Metal oxide nanomaterials have extensive cell killing activity against bacteria, fungi, and viruses. The remarkable properties of copper oxide (CuO) have introduced it as one of the most important transition metal oxides. The reports confirmed the potential antibacterial activities of copper oxide nanoparticles. In this research, for the first time, nanocomposite was obtained from a combination of three active materials (zinc oxide and copper nanoparticles and tranexamic acid) to be used as a coating scaffold. Its performance was then evaluated on sterile cotton gauze. Novel nano-based treatments can enhance the life expectancy. © 2021, The Regenerative Engineering Society.