Six New Triterpenoids From the Root of Potentilla Reptans and Their Cardioprotective Effects in Silico

Six New Triterpenoids From the Root of Potentilla Reptans and Their Cardioprotective Effects in Silico Publisher Pubmed

Enayati A^{1, 2} ; Salehi A¹ ; Alilou M³ ; Stuppner H³ ; Mirzaei H¹ ; Omraninava A² ; Khori V¹ ; Yassa N²

Show Affiliations

1. Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
2. Department of Pharmacognosy, Faculty of Pharmacy and Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Institute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria

Source: Natural Product Research Published:2022

Abstract

Tormentic acid ester glucosides derivatives (1, 2 and 4), 3-oxoursane ester glycoside (3) and 11-methoxy-ursane ester glycosides (5, 6) as six new triterpenoids, along with catechin were isolated from the ethyl acetate fraction of Potentilla reptans root (Et) methanolic extract. The structures of the compounds were elucidated by 1D, 2D NMR, IR and MS spectroscopy. Additionally, isolated triterpenoid compounds (1–6) and catechin were evaluated for their cardioprotective effects via glycogen synthase kinase 3β (GSK-3β) and glucocorticoid regulated kinase-1 (SGK1) protein kinase inhibition by Molecular Docking. Compound 1 and catechin (compound 7) exhibited significant inhibitory effects against GSK-3β and SGK1 protein kinases with a binding energy value −9.1 and −8.8 kcal/mol, respectively. Hence, Et can be a suitable natural candidate to protect cardiomyocytes injury. © 2021 Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Enayati A, et al.. "Six New Triterpenoids From the Root of Potentilla Reptans and Their Cardioprotective Effects in Silico." Natural Product Research, vol. 36, no. 10, 2022, pp. 2504-2512.
APA	Enayati A, Salehi A, Alilou M, Stuppner H, Mirzaei H, Omraninava A, Khori V, Yassa N (2022). Six New Triterpenoids From the Root of Potentilla Reptans and Their Cardioprotective Effects in Silico. Natural Product Research, 36(10), 2504-2512.
Chicago	Enayati A, Salehi A, Alilou M, Stuppner H, Mirzaei H, Omraninava A, Khori V, Yassa N. "Six New Triterpenoids From the Root of Potentilla Reptans and Their Cardioprotective Effects in Silico." Natural Product Research 36, no. 10 (2022): 2504-2512.
Harvard	Enayati A et al. (2022) 'Six New Triterpenoids From the Root of Potentilla Reptans and Their Cardioprotective Effects in Silico', Natural Product Research, 36(10), pp. 2504-2512.
Vancouver	Enayati A, Salehi A, Alilou M, Stuppner H, Mirzaei H, Omraninava A, et al.. Six New Triterpenoids From the Root of Potentilla Reptans and Their Cardioprotective Effects in Silico. Natural Product Research. 2022;36(10):2504-2512.
BibTex	@article{ author = {Enayati A and Salehi A and Alilou M and Stuppner H and Mirzaei H and Omraninava A and Khori V and Yassa N}, title = {Six New Triterpenoids From the Root of Potentilla Reptans and Their Cardioprotective Effects in Silico}, journal = {Natural Product Research}, volume = {36}, number = {10}, pages = {2504-2512}, year = {2022} }
RIS	TY - JOUR AU - Enayati A AU - Salehi A AU - Alilou M AU - Stuppner H AU - Mirzaei H AU - Omraninava A AU - Khori V AU - Yassa N TI - Six New Triterpenoids From the Root of Potentilla Reptans and Their Cardioprotective Effects in Silico JO - Natural Product Research VL - 36 IS - 10 SP - 2504 EP - 2512 PY - 2022 ER -

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