Can Physiologic Menstrual Cycle Change Serum Lamotrigine Concentration?

Can Physiologic Menstrual Cycle Change Serum Lamotrigine Concentration? Publisher Pubmed

Asadollahi M¹ ; Ramezani M¹ ; Karimialavijeh E² ; Tavakolian M¹ ; Ramezani M¹

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1. Shahid Beheshti University of Medical Sciences, Loghman Hakim Hospital, Department of Neurology, Iran
2. Tehran University of Medical Sciences, Shariaty Hospital, Department of Emergency Medicine, Iran

Source: Seizure Published:2015

Abstract

Purpose: The present study aimed to compare the serum LTG levels during the early-/mid-follicular (low estradiol) and mid-luteal (high estradiol) phases of the physiologic menstrual cycle. Method: In a cross-sectional study, 20 women with epilepsy were recruited. Participants had been on monotherapy with LTG for at least two months. All the subjects had normal menstrual cycles. Blood samples for each patient were taken whilst fasting during the early-/mid-follicular (Days 3-5) and mid- luteal phases (Days 20-24). All samples were analyzed in batched assays. A comparison of the serum LTG levels was carried out using the Mann-Whitney U test Data were analyzed with the SPSS program, version 16 (SPSS Inc., Chicago, IL), p-values below 0.05 were considered significant. Results: The mean serum LTG levels for the early-/mid-follicular and mid-luteal phases were 4.28 ± 2.76 mg/ml (SD) and 3.86 ± 2.06 mg/ml (SD), respectively. There was no statistically significant difference in serum LTG level between the (low estradiol) early-/mid-follicular and (high estradiol) mid-luteal phases in our patients (p-value = 0.23). Conclusion: The serum level of LTG does not alter significantly during the menstrual cycle. © 2015 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

Style	Citing Format
MLA	Asadollahi M, et al.. "Can Physiologic Menstrual Cycle Change Serum Lamotrigine Concentration?." Seizure, vol. 33, no. , 2015, pp. 35-37.
APA	Asadollahi M, Ramezani M, Karimialavijeh E, Tavakolian M, Ramezani M (2015). Can Physiologic Menstrual Cycle Change Serum Lamotrigine Concentration?. Seizure, 33(), 35-37.
Chicago	Asadollahi M, Ramezani M, Karimialavijeh E, Tavakolian M, Ramezani M. "Can Physiologic Menstrual Cycle Change Serum Lamotrigine Concentration?." Seizure 33, no. (2015): 35-37.
Harvard	Asadollahi M et al. (2015) 'Can Physiologic Menstrual Cycle Change Serum Lamotrigine Concentration?', Seizure, 33(), pp. 35-37.
Vancouver	Asadollahi M, Ramezani M, Karimialavijeh E, Tavakolian M, Ramezani M. Can Physiologic Menstrual Cycle Change Serum Lamotrigine Concentration?. Seizure. 2015;33():35-37.
BibTex	@article{ author = {Asadollahi M and Ramezani M and Karimialavijeh E and Tavakolian M and Ramezani M}, title = {Can Physiologic Menstrual Cycle Change Serum Lamotrigine Concentration?}, journal = {Seizure}, volume = {33}, number = {}, pages = {35-37}, year = {2015} }
RIS	TY - JOUR AU - Asadollahi M AU - Ramezani M AU - Karimialavijeh E AU - Tavakolian M AU - Ramezani M TI - Can Physiologic Menstrual Cycle Change Serum Lamotrigine Concentration? JO - Seizure VL - 33 IS - SP - 35 EP - 37 PY - 2015 ER -

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