Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Outcome of Treatment With Intravenous Alteplase in Acute Stroke Patients Publisher



Nemati H1 ; Saadat P2 ; Ahmadi Ahangar A3 ; Nematian V2 ; Alijanpour S4 ; Bijani A5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, Babol University of Medical Sciences, Babol, Iran
  2. 2. Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
  3. 3. Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
  4. 4. Students Scientific Research Center, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

Source: Journal of Babol University of Medical Sciences Published:2023


Abstract

Background and Objective: Stroke is one of the main causes of death and disability in the world, and its treatment includes the re-supply of blood to the brain tissue using different methods, including alteplase injection. The aim of this study is to determine the outcome of treatment with intravenous alteplase. Methods: This cross-sectional study was conducted on all stroke patients referred to Babol Rouhani Hospital in 2019-2021. Patients were divided into two groups receiving intravenous alteplase and routine and supportive treatment groups. Demographic information and the scores of National Institutes of Health Stroke Scale (NIHSS) to evaluate the improvement of stroke symptoms and Modified Rankin Scale (mRS) to evaluate the severity of disability in three periods of 7, 30 and 90 days were investigated and compared. Findings: Out of 100 studied patients, 49 people were in alteplase group and 51 people were in routine and supportive treatment group. In examining the NIHSS scale of patients in three follow-up periods, there was a significant difference in the alteplase group compared to the routine and supportive treatment group (p<0.001). Moreover, regarding the mRS scale, on the 90th day (0.65±0.80 vs. 1.55±1.11) unlike the 30th day (1.65±1.07 vs. 1.31±0.92), there was a significant difference between the two groups receiving alteplase and the routine and supportive treatment group (p<0.001). Conclusion: The results of the study showed that treatment with intravenous alteplase can have a suitable effect on neurological disorders after a stroke and can improve the level of disability in daily functioning in the long term, up to the 90th day of patient follow-up. © 2023, Babol University of Medical Sciences. All rights reserved.
Related Docs
1. Direct Mechanical Thrombectomy Versus Prior Bridging Intravenous Thrombolysis in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis, Life (2023)
2. Intravenous Thrombolysis in Ischemic Stroke Patients With a Prior Intracranial Hemorrhage: A Meta-Analysis, Therapeutic Advances in Neurological Disorders (2022)
3. Mediatory Role of the Serum Mineral Level and Discharge Disability of Stroke Survivors, Caspian Journal of Internal Medicine (2024)
4. New-Onset Constipation After Stroke: Caspian Nursing Process Projects, Journal of Holistic Nursing and Midwifery (2022)
5. Relationship Between Serum Sodium Level and Impairment and Disability in Stroke Patients, Journal of Babol University of Medical Sciences (2022)
6. Caspian Nursing Process: Impactions on New-Onset Constipations in Admission, Discharge, and Follow-Up of Acute Stroke Patients, Iranian Journal of Nursing and Midwifery Research (2022)
7. Therapeutic Potential of Stem Cells for Treatment of Neurodegenerative Diseases, Biotechnology Letters (2020)