Anticancer Activity of Graphene Oxide/5-Fu on Ct26 Dsred Adenocarcinoma Cell Line Publisher



Afarideh B^{1, 4} ; Rajabibazl M^{1, 2} ; Omidi M³ ; Rahimpour A² ; Khodabakhshi R⁴ ; Sarvarian S⁴
Source: Oriental Journal of Chemistry Published:2018

Abstract

Cancer is one of the greatest health challenges in the world. Every year, many people die because of cancer. Chemotherapy is one of the treatment options in cancer disease. Fluorouracil) (5-FU) is one of the chemotherapy drugs, but it has relatively low toxic effect on tumor cells when it is used on free form, which also results in its poor efficacy. GO (graphene oxide) has a single-atomic layer and has several functional groups such as epoxide, carbonyl, carboxyl and hydroxyl which makes it a suitable carrier for drug loading. In the present study, we loaded 5-FU on GO nano-carrier to produce GO/5-FU, and characterized it by FT-IR. CT26 dsRED adenocarcinoma cell line was treated with GO/5-FU, free 5-FU, GO, and PBS (Phosphate buffer saline). The results showed significant inhibition of the CT26 dsRED cells using GO/5-FU compared to free 5-FU (P<0.05). Therefore, loaded 5-FU on GO (GO/5-FU) could be a new approach for optimization of 5-FU tumor cytotoxicity. © 2018 Oriental Scientific Publishing Company. All Rights Reserved.