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The Role of the Cx3cl1/Cx3cr1 Axis As Potential Inflammatory Biomarkers in Subjects With Periodontitis and Rheumatoid Arthritis: A Systematic Review Publisher Pubmed



Alarconsanchez MA1 ; Becerraruiz JS2 ; Guerrerovelazquez C3 ; Mosaddad SA4, 5 ; Heboyan A4, 6, 7
Authors
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Authors Affiliations
  1. 1. Biomedical Science, Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero, Guerrero, Mexico
  2. 2. Institute of Research of Bioscience, University Center of Los Altos, University of Guadalajara, Guadalajara, Mexico
  3. 3. Research Center in Molecular Biology of Chronic Diseases, Southern University Center, University of Guadalajara, Guadalajara, Mexico
  4. 4. Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
  5. 5. Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia
  7. 7. Department of Prosthodontics, Tehran University of Medical Sciences, Tehran, Iran

Source: Immunity# Inflammation and Disease Published:2024


Abstract

Objective: This systematic review aimed to investigate the role of the C-X3-C motif ligand 1/chemokine receptor 1 C-X3-C motif (CX3CL1/CX3CR1) axis in the pathogenesis of periodontitis. Furthermore, as a secondary objective, we determine whether the CX3CL1/CX3CR1 axis could be considered complementary to clinical parameters to distinguish between periodontitis and rheumatoid arthritis (RA) and/or systemically healthy subjects. Methods: The protocol used for this review was registered in OSF (10.17605/OSF.IO/KU8FJ). This study was designed following Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. Records were identified using different search engines (PubMed/MEDLINE, Scopus, Science Direct, and Web of Science) from August 10, 2006, to September 15, 2023. The observational studies on human subjects diagnosed with periodontitis and RA and/or systemically healthy were selected to analyze CX3CL1 and CX3CR1 biomarkers. The methodological validity of the selected articles was assessed using NIH. Results: Six articles were included. Biological samples (gingival crevicular fluid [GCF], saliva, gingival tissue biopsies, serum) from 379 subjects (n = 275 exposure group and n = 104 control group) were analyzed. Higher CX3CL1 and CX3CR1 chemokine levels were found in subjects with periodontitis and RA compared with periodontal and systemically healthy subjects. Conclusion: Very few studies highlight the role of the CX3CL1/CX3CR1 axis in the pathogenesis of periodontitis; however, increased levels of these chemokines are observed in different biological samples (GCF, gingival tissue, saliva, and serum) from subjects with periodontitis and RA compared with their healthy controls. Future studies should focus on long-term follow-up of subjects and monitoring changes in cytokine levels before and after periodontal therapy to deduce an appropriate interval in health and disease conditions. © 2024 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.
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