Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Covid-19 in Adults With Congenital Heart Disease Publisher Pubmed



Broberg CS1 ; Kovacs AH1 ; Sadeghi S2 ; Rosenbaum MS3 ; Lewis MJ3 ; Carazo MR4 ; Halpern DG5 ; Feinberg J5 ; Galilea FA6 ; Baraona F6 ; Cedars AM7 ; Ko JM7 ; Porayette P8 ; Maldonado J8 Show All Authors
Authors
  1. Broberg CS1
  2. Kovacs AH1
  3. Sadeghi S2
  4. Rosenbaum MS3
  5. Lewis MJ3
  6. Carazo MR4
  7. Halpern DG5
  8. Feinberg J5
  9. Galilea FA6
  10. Baraona F6
  11. Cedars AM7
  12. Ko JM7
  13. Porayette P8
  14. Maldonado J8
  15. Sarubbi B9
  16. Fusco F9
  17. Frogoudaki AA10
  18. Nir A11
  19. Chaudhry A12
  20. John AS13
  21. Karbassi A14
  22. Hoskoppal AK15
  23. Frischhertz BP16
  24. Hendrickson B17
  25. Bouma BJ18
  26. Rodriguezmonserrate CP19
  27. Broda CR20
  28. Tobler D21
  29. Gregg D22
  30. Martinezquintana E23
  31. Yeung E24
  32. Krieger EV25
  33. Rupertirepilado FJ26
  34. Giannakoulas G27
  35. Lui GK28
  36. Ephrem G29
  37. Singh HS30
  38. Almeneisi HM31
  39. Bartlett HL32
  40. Lindsay I33
  41. Grewal J34
  42. Nicolarsen J35
  43. Araujo JJ36
  44. Cramer JW37
  45. Bouchardy J38
  46. Al Najashi K39
  47. Ryan K40
  48. Alshawabkeh L41
  49. Andrade L42
  50. Ladouceur M43
  51. Schwerzmann M44
  52. Greutmann M45
  53. Meras P46
  54. Ferrero P47
  55. Dehghani P48
  56. Tung PP49
  57. Garciaorta R50
  58. Tompkins RO51
  59. Gendi SM52
  60. Cohen S53
  61. Klewer S54
  62. Hascoet S55
  63. Mohammadzadeh S56
  64. Upadhyay S57
  65. Fisher SD58
  66. Cook S59
  67. Cotts TB60
  68. Aboulhosn JA2
Show Affiliations
Authors Affiliations
  1. 1. Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States
  2. 2. Ahmanson/UCLA Adult Congenital Heart Center, Los Angeles, CA, United States
  3. 3. Division of Cardiology, Columbia University Medical Center, New York, NY, United States
  4. 4. Division of Cardiology, Emory University School of Medicine, Atlanta, GA, United States
  5. 5. Division of Cardiology, York University Langone Health, New York, NY, United States
  6. 6. Instituto Nacional del Torax - Pontificia Universidad Catolica de Chile, Santiago, Chile
  7. 7. Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
  8. 8. Division of Cardiology, University of Iowa Stead Family Children's Hospital, Iowa City, IA, United States
  9. 9. Monaldi Hospital, Adult Congenital Heart Disease Unit, Naples, Italy
  10. 10. Second Cardiology Department, ATTIKON University Hospital, Athens, Greece
  11. 11. Shaare Zedek Medical Center, Jerusalem, Israel
  12. 12. Penn State Hershey Heart and Vascular Institute, State College, PA, United States
  13. 13. Division of Cardiology, Children's National Hospital, Washington, DC, United States
  14. 14. McMaster University, Hamilton, ON, Canada
  15. 15. UPMC Adult Congenital Heart Disease Program, Pittsburgh, PA, United States
  16. 16. Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, United States
  17. 17. University of Tennessee Health Science Center, Le Bonheur Heart Institute, Memphis, TN, United States
  18. 18. Department of Cardiology, Amsterdam University Medical Center, Amsterdam, Netherlands
  19. 19. Department of Cardiology, Boston Children's Hospital, Boston, MA, United States
  20. 20. Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States
  21. 21. Division of Cardiology, University Hospital of Basel, Basel, Switzerland
  22. 22. Division of Cardiology, Medical University of South Carolina, Charleston, SC, United States
  23. 23. Cardiology Service, Universitario Insular-Materno Infantil, Las Palmas de Gran Canaria, Spain
  24. 24. Anschutz Medical Campus, Colorado's Adult and Teen Congenital Heart Program, Aurora, CO, United States
  25. 25. Division of Cardiology, University of Washington School of Medicine, Seattle, WA, United States
  26. 26. Division of Cardiology, University Hospital Geneva, Geneva, Switzerland
  27. 27. Cardiology Department, AHEPA University Hospital, Thessaloniki, Greece
  28. 28. Division of Cardiovascular Medicine and Pediatric Cardiology, Stanford University School of Medicine, Stanford, CA, United States
  29. 29. Indiana University School of Medicine, Krannert Institute of Cardiology, Indianapolis, IN, United States
  30. 30. Weill Cornell Medicine, New York Presbyterian Hospital, Department of Medicine and Pediatrics, New York, NY, United States
  31. 31. Cincinnati Children's Hospital Medical Center, The Heart Institute, Cincinnati, OH, United States
  32. 32. Department of Pediatrics and Medicine, University of Wisconsin, Madison, WI, United States
  33. 33. Division of Pediatric Cardiology, University of Utah, Salt Lake City, UT, United States
  34. 34. University of British Columbia, St. Paul's Hospital, Vancouver, British Colombia, Canada
  35. 35. Providence Adult and Teen Congenital Heart Program, Pediatric and Adult Cardiology, Spokane, WA, United States
  36. 36. Department of Pediatric and Adult Congenital Heart Disease, Somer Incare Cardiovascular Center, Rionegro, Colombia
  37. 37. Division of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, NE, United States
  38. 38. Department of Cardiology and Cardiac Surgery, University Hospital Lausanne, Lausanne, Switzerland
  39. 39. Pediatric Cardiology Department, Prince Sultan Cardiac Center, Riyadh, Saudi Arabia
  40. 40. OSF Healthcare Children's Hospital of Illinois, Adult Congenital Heart Program, Peoria, IL, United States
  41. 41. Department of Cardiovascular Medicine, University of California San Diego, La Jolla, CA, United States
  42. 42. Division of Cardiology, Hospital of University of Pennsylvania, Philadelphia, PA, United States
  43. 43. Hopital Europeen Georges Pompidou, Adult Congenital Heart Disease Unit, Paris, France
  44. 44. University Hospital Inselspital, Center for Congenital Heart Disease, Bern, Switzerland
  45. 45. Department of Cardiology, University of Zurich, Zurich, Switzerland
  46. 46. University Hospital La Paz, Madrid, Spain
  47. 47. ASST Papa Giovanni XXIII, Cardiovascular Department, University of Milano, Bergamo, Italy
  48. 48. Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada
  49. 49. University of Texas at Houston, Adult Congenital Heart Disease, Houston, TX, United States
  50. 50. Cardiology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain
  51. 51. Cedars-Sinai Medical Center, The Geurin Family Congenital Heart Program, Los Angeles, CA, United States
  52. 52. West Virginia University, Adult Congenital Heart Disease Program, Morgantown, WV, United States
  53. 53. Medical College of Wisconsin, Adult Congenital Heart Disease Program, Milwaukee, WI, United States
  54. 54. Division of Cardiology, University of Arizona, Tucson, AZ, United States
  55. 55. Hopital Marie Lannelongue, Le Plessis Robinson, France
  56. 56. Tehran University of Medical Sciences, Tehran, Iran
  57. 57. Connecticut Children's Medical Center, Pediatric Cardiology Hartford, CT, United States
  58. 58. Department of Medicine and Pediatrics, University of Maryland School of Medicine, Baltimore, MD, United States
  59. 59. Helen DeVos Children's Hospital, Adult Congenital Heart Center, Grand Rapids, MI, United States
  60. 60. Department of Medicine and Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States

Source: Journal of the American College of Cardiology Published:2021


Abstract

Background: Adults with congenital heart disease (CHD) have been considered potentially high risk for novel coronavirus disease-19 (COVID-19) mortality or other complications. Objectives: This study sought to define the impact of COVID-19 in adults with CHD and to identify risk factors associated with adverse outcomes. Methods: Adults (age 18 years or older) with CHD and with confirmed or clinically suspected COVID-19 were included from CHD centers worldwide. Data collection included anatomic diagnosis and subsequent interventions, comorbidities, medications, echocardiographic findings, presenting symptoms, course of illness, and outcomes. Predictors of death or severe infection were determined. Results: From 58 adult CHD centers, the study included 1,044 infected patients (age: 35.1 ± 13.0 years; range 18 to 86 years; 51% women), 87% of whom had laboratory-confirmed coronavirus infection. The cohort included 118 (11%) patients with single ventricle and/or Fontan physiology, 87 (8%) patients with cyanosis, and 73 (7%) patients with pulmonary hypertension. There were 24 COVID-related deaths (case/fatality: 2.3%; 95% confidence interval: 1.4% to 3.2%). Factors associated with death included male sex, diabetes, cyanosis, pulmonary hypertension, renal insufficiency, and previous hospital admission for heart failure. Worse physiological stage was associated with mortality (p = 0.001), whereas anatomic complexity or defect group were not. Conclusions: COVID-19 mortality in adults with CHD is commensurate with the general population. The most vulnerable patients are those with worse physiological stage, such as cyanosis and pulmonary hypertension, whereas anatomic complexity does not appear to predict infection severity. © 2021 American College of Cardiology Foundation
Other Related Docs
9. A Case of Multiple Large Left Ventricular Clots in a Patient With Covid-19, International Cardiovascular Research Journal (2021)