Comparative Analysis of Biochemical Parameters Across Different Stages of Kidney Disease: From Early Kidney Disease to Dialysis-Dependent Renal Failure; تا نارسایی کلیه در حال دیالیزتحلیل مقایسه ای پارامترهای بیوشیمیایی در مراحل مختلف بیماری کلیه: از بیماری اولیه



Alghanim NTJ ; Abbas HJ ; Choobineh H ; Majidi Z ; Dashti N
Source: Journal of Payavard Salamat Published:2025

Abstract

Background and Aim: This study investigated the biochemical profiles of individuals with different stages of kidney disease, including those with kidney disease without hemodialysis, chronic kidney disease without hemodialysis, and individuals with renal failure undergoing hemodialysis treatment, to clarify the role of mineral markers, inflammation, and kidney function in the complications of this disease. Materials and Methods: This case-control study was conducted with 180 participants aged 18 to 81 years in Iraq. Participants were divided into four groups: the case group (including individuals with kidney disease not on dialysis, chronic kidney disease not on dialysis, and kidney failure treated with dialysis) and the control group, which included healthy individuals. Blood levels of urea, creatinine, calcium, phosphorus, vitamin D3, parathyroid hormone (PTH), high-sensitivity C-reactive protein (hs-CRP), and cystatin C were measured. Results: The results showed that the levels of blood urea, calcium, vitamin D3, cystatin C and hs-CRP were significantly different between the different groups. The mean creatinine in the non-dialysis kidney disease group (3.98±1.77 mg/dL) and non-dialysis chronic kidney disease (4.59±1.63 mg/dL) was different from the dialysis kidney failure group (11.03±3.35 mg/dL) (P=0.001), but there was no significant difference between the two groups of kidney disease without dialysis and chronic kidney disease without dialysis. The phosphorus concentration was significant in all groups (P=0.001) and the highest value was observed in the dialysis kidney failure group. The PTH level was not significantly different between the two groups of non-dialysis, but there was a significant difference compared to the dialysis kidney failure group (P=0.001). Cystatin C was not significantly different in the two non-dialysis groups, but was significantly higher (P=0.001) compared with the renal failure group on dialysis (7.06±1.61 mg/dL). Conclusion: This study demonstrated that regular monitoring of biochemical biomarkers is essential for the timely diagnosis and effective management of kidney disease. It also highlights the importance of paying attention to metabolic and inflammatory abnormalities in patients with kidney disease (especially in patients on dialysis), including extensive changes in biochemical, hormonal, and inflammatory factors levels that often occur due to severe impairment of kidney function and the dialysis process. © 2025 Elsevier B.V., All rights reserved.