Correlation Between Cd15 Expression and Progression of Gastric Adenocarcinoma



Yazdi SAM¹ ; Jamali D² ; Mashadi S² ; Nazar E² Show Affiliations
Source: Surgical Chronicles Published:2023

Abstract

Background: Gastric cancer is one of the main causes of mortality due to malignancy. Tumor-associated neutrophil (TAN) has an immunosuppressor role and is related to prognosis. But the mechanism is unknown. The present study investigated the role of CD15 (TAN) in gastric cancer. Methods and Materials: Our study was cross-sectional and made on 40 recognized patients of gastric cancer. Immunohistochemical staining for CD15 was done on gastric cancer tissues. Tumor behaviors were estimated by histopathological assessments. Results: CD15 positivity was revealed in 17 (42.5%) of all evaluated patients. The evaluation of the connection between CD15 expression and demographic data and tumor characteristics revealed no significant relationship between CD15 expression and patients’ sex, age, tumor site, and size, subtype of tumor, tumor grade and stage, perineural invasion, and lymphovascular invasion (P-value>0.05). Conclusion: Gastric cancer prognosis is related to diverse immune cells in the tumor microenvironment but in our society, the CD15 expression hasn’t any relationship with aggressive histopathologic features of this tumor. © 2023 Surgical Society of Northern Greece. All rights reserved.