Tehran University of Medical Sciences

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Tailoring La1-Xsrxmno3 (0.25 ≤ X ≤ 0.35) Nanoparticles for Self-Regulating Magnetic Hyperthermia Therapy: An in Vivo Study Publisher Pubmed



Soleymani M1 ; Edrissi M2 ; Alizadeh AM3
Authors
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Authors Affiliations
  1. 1. Department of Chemical Engineering, Faculty of Engineering, Arak University, Arak, 38156-8-8349, Iran
  2. 2. Department of Chemical Engineering, Amirkabir University of Technology, Hafez Ave., Tehran, 15875-4413, Iran
  3. 3. Cancer Research Center, Tehran University of Medical Sciences, Keshavarz Ave., Tehran, 14197-33141, Iran

Source: Journal of Materials Chemistry B Published:2017


Abstract

A careful design of La1-xSrxMnO3 (0.25 ≤ x ≤ 0.35) nanoparticles (NPs) was made to prepare a self-controlled heating agent for magnetic hyperthermia therapy (MHT). The results showed that the magnetic properties and heating efficacy of the tailored La1-xSrxMnO3 NPs are strongly dependent on the doping level of La/Sr cations, so that La0.73Sr0.27MnO3 NPs possessed the highest saturation magnetization and heating efficacy in response to safe alternating magnetic fields used in biomedical applications (H = 3.4-5.0 mT and f = 120 kHz). Furthermore, to improve the biocompatibility of the La0.73Sr0.27MnO3 NPs, the surface of the NPs was coated with a thin silica shell, and then the therapeutic efficacy of MHT using the silica-coated La0.73Sr0.27MnO3 NPs was investigated using a typical animal model of breast cancer. The results showed that in the control group, the mean tumor volume increased up to 300% over 6 days, while in the MHT group, the mean tumor volume decreased about 85% during the same period of time (Pvalue = 0.002). The outcomes of this study indicate that silica-coated La0.73Sr0.27MnO3 NPs are a promising tool for self-regulating MHT. © 2017 The Royal Society of Chemistry.