Development of an 111In-Labeled Dihydropyridine Complex for L-Type Calcium Channel Imaging

Development of an 111In-Labeled Dihydropyridine Complex for L-Type Calcium Channel Imaging Publisher

Firouzyar T¹ ; Jalilian AR² ; Shafieeardestani M¹ ; Aboudzadeh MR² ; Fazaeli Y² ; Bolourinovin F² ; Mirzaii M² ; Khalaj A¹

Show Affiliations

1. Tehran University of Medical Sciences, Tehran, Iran
2. Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), P. O. Box 14395-836, Tehran, Iran

Source: Journal of Radioanalytical and Nuclear Chemistry Published:2015

Abstract

[111In]-DTPA-Amlodipine complex ([111In]-DTPA-AMLO) was prepared starting high purity [111In]indium chloride and conjugated DTPA-AMLO in 30 min at room temperature in acetate buffer in high radiochemical purity (>99 %, RTLC/HPLC; specific activity: 8–10 GBq/mmol). The log P, stability, biodistribution studies and imaging studies in untreated and amlodipine-pretreated rats were determined. The tracer is mostly washed out through kidneys as expected for a dihydropyridine compound. Blocking studies demonstrated high specific binding of the tracer in calcium channel-rich organs including intestine, heart and colon. SPECT images fully supported above results in normal and treated rats. © 2014, Akademiai Kiado, Budapest, Hungary.

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Style	Citing Format
MLA	Firouzyar T, et al.. "Development of an 111In-Labeled Dihydropyridine Complex for L-Type Calcium Channel Imaging." Journal of Radioanalytical and Nuclear Chemistry, vol. 303, no. 3, 2015, pp. 2361-2369.
APA	Firouzyar T, Jalilian AR, Shafieeardestani M, Aboudzadeh MR, Fazaeli Y, Bolourinovin F, Mirzaii M, Khalaj A (2015). Development of an 111In-Labeled Dihydropyridine Complex for L-Type Calcium Channel Imaging. Journal of Radioanalytical and Nuclear Chemistry, 303(3), 2361-2369.
Chicago	Firouzyar T, Jalilian AR, Shafieeardestani M, Aboudzadeh MR, Fazaeli Y, Bolourinovin F, Mirzaii M, Khalaj A. "Development of an 111In-Labeled Dihydropyridine Complex for L-Type Calcium Channel Imaging." Journal of Radioanalytical and Nuclear Chemistry 303, no. 3 (2015): 2361-2369.
Harvard	Firouzyar T et al. (2015) 'Development of an 111In-Labeled Dihydropyridine Complex for L-Type Calcium Channel Imaging', Journal of Radioanalytical and Nuclear Chemistry, 303(3), pp. 2361-2369.
Vancouver	Firouzyar T, Jalilian AR, Shafieeardestani M, Aboudzadeh MR, Fazaeli Y, Bolourinovin F, et al.. Development of an 111In-Labeled Dihydropyridine Complex for L-Type Calcium Channel Imaging. Journal of Radioanalytical and Nuclear Chemistry. 2015;303(3):2361-2369.
BibTex	@article{ author = {Firouzyar T and Jalilian AR and Shafieeardestani M and Aboudzadeh MR and Fazaeli Y and Bolourinovin F and Mirzaii M and Khalaj A}, title = {Development of an 111In-Labeled Dihydropyridine Complex for L-Type Calcium Channel Imaging}, journal = {Journal of Radioanalytical and Nuclear Chemistry}, volume = {303}, number = {3}, pages = {2361-2369}, year = {2015} }
RIS	TY - JOUR AU - Firouzyar T AU - Jalilian AR AU - Shafieeardestani M AU - Aboudzadeh MR AU - Fazaeli Y AU - Bolourinovin F AU - Mirzaii M AU - Khalaj A TI - Development of an 111In-Labeled Dihydropyridine Complex for L-Type Calcium Channel Imaging JO - Journal of Radioanalytical and Nuclear Chemistry VL - 303 IS - 3 SP - 2361 EP - 2369 PY - 2015 ER -

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